نتایج جستجو برای: sarcoma tumors
تعداد نتایج: 244044 فیلتر نتایج به سال:
A variety of transplantable mouse, rat, hamster, and ehieken tumors have been suecessfully stored at 7 6 ~ C. (dry-ice chest) for a period of 1 year. These tumors are seven sarcomas, a mammary carcinoma, a skin carcinoma, a bladder carcinoma, a lung carcinoma, two lymphosarcomas, a glioma, a leukemia, a virus leukemia, a pancreatic tumor, and a small intestine tumor. Transplantability of a majo...
SUMMARY Hamsters inoculated with murine sarcoma virus (Moloney) of mouse or rat origin developed nonregressing, metastasizing, undifferentiating sarcomas. Light microscopy and ultrastructural studies of the hamster sarcoma revealed less tumor-cell differentiation than reported for the mouse or rat. Cell-free extracts prepared from the hamster tumors were oncogenic only in animals of the same sp...
Neuroblastoma-like schwannoma is known as a rare unusual variant of with difficulties differential diagnosis neuroblastoma, Ewing sarcoma/peripheral neuroectodermal tumor and other cutaneous small round cell tumors. Herein, we describe neuroblastoma-like that was presented painless lesion on the dorsal side left hand in 39-year-old woman. Composed collagen fibers central core rosettes diffuse e...
Sarcomas are thought to originate from mes-enchymal tissue, and account for 1% of adult solid malignancies and over 20% of pediatric solid malignances. Nearly 11,000 people in the USA and 200,000 people in the world will be diagnosed with sarcomas each year [101]. When they metastasize, sarcomas typically have a very poor outcome. Unlike other types of tumors, the molecular basis and accompanyi...
Soft tissue sarcoma (STS) is a heterogeneous family of rare mesenchymal tumors, characterized by histopathological and molecular diversity. Tissue microarray (TMA) tool that allows performing research in orphan diseases more efficient cost-effective way. TMAs are paraffin blocks consisting multiple small representative cores from biological samples, for example, donors, diverse sites disease, o...
Limited progress has been made in the treatment of advanced-stage pediatric solid tumors despite the accelerated pace of cancer discovery over the last decade. Tyrosine kinase inhibition is one tractable therapeutic modality for treating human malignancy. However, little is known about the kinases critical to the development or maintenance of many pediatric solid tumors such as Ewing sarcoma. U...
PURPOSE A low mutation rate seems to be a general feature of pediatric cancers, in particular in oncofusion gene-driven tumors. Genetically, Ewing sarcoma is defined by balanced chromosomal EWS/ETS translocations, which give rise to oncogenic chimeric proteins (EWS-ETS). Other contributing somatic mutations involved in disease development have only been observed at low frequency. EXPERIMENTAL...
Synovial sarcoma is a soft tissue malignancy defined by the SYT-SSX fusion oncogene. Demonstration of the t(X;18) by cytogenetics, fluorescence in situ hybridization or reverse-transcriptase polymerase chain reaction has become the gold standard for diagnosis, but practical considerations limit the availability of these methods. Gene expression profiling studies performed by several independent...
The potential of cancer drugs is not fully exploited due to low tumor uptake and occurrence systemic side effects, limiting maximum tolerated dose. Actively targeted nanocarriers improve efficacy while minimizing off-target toxicity. Herein, it the first time a drug-delivery platform for heat-triggered intravascular drug release described, based on synthetic phosphatidyl-(oligo)-glycerols from ...
SPONTANEOUS BONE tumors in mice are rare. Pybus and Miller (1, 2) described a subline of Simpson mice which had a high incidence of bone tumors, but descendants of these mice no longer develop bone tumors. Apart from this series, most reports have been of single tumors usually in C3H mice (3) or their hybrids (4). Dunn (personal communication) observed an osteogenic sarcoma with metastases in a...
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