Soft tissue sarcomas comprise a heterogeneous group of mesenchymal tumors with varying biological behavior ranging from indolent tumors with no or minimal metastatic risk to aggressive and frequently metastasizing tumors. Among the more common aggressive adult soft tissue sarcomas are malignant fibrous histiocytoma, synovial sarcoma and liposarcoma. Matrix metalloproteinases are enzymes which p...

Uterine sarcomas account for 1% of female genital tract cancers and 2-5% of uterine malignancies (Major et al., 1993; Tavassoli & Devilee, 2003). This heterogenous group of tumors derives from uterine mesodermal tissue and because of their rarity and histopathological diversity, there is a lack of consensus on prognostic factors and optimal treatment. Uterine sarcomas were classified into 4 mai...

BACKGROUND The purpose of this study was to investigate the role of Nucleus accumbens-associated 1 (NAC1) in the development of uterine sarcomas. MATERIALS AND METHODS NAC1 expression and localization in the normal myometrium, benign leiomyoma, and uterine sarcoma were assessed with immunohistochemistry. NAC1-specific siRNA was used to inactivate NAC1 for in vitro biological assays. RESULTS...

Mice allografted with different sarcomas, induced by the Schmidt-Ruppin variant of Rous sarcoma virus (RSV-SR), showed a resistance against subsequent isografting of 9 different Rous sarcomas. Transplantation resistance could also be induced by Rous mouse tumor cells x-irradiated with 8000 r or with cell-free tumor extracts, containing no demonstrable virus. No transplantation resistance could ...

BACKGROUND Recently, recurrent point mutations in the telomerase reverse transcriptase (TERT) promoter region have been found in many human cancers, leading to a new transcription factor binding site, increased induction of TERT and subsequently to telomere maintenance. We determined the prevalence of TERT promoter mutations in soft tissue sarcomas of 341 patients comprising 16 entities and in ...

primary sarcomas of the kidney are exceptional. among renal sarcomas, leiomyosarcoma is the most common histologic subtype amounting to 50-60% of all cases. the tumor usually arises from either the renal capsule or smooth muscle tissue in the renal pelvic wall. in this paper, we report a patient with leiomyosarcoma of the kidney presented with non-specific abdominal pain and a palpable mass. hi...

Myeloid sarcoma represents the proliferation of myeloblasts of acute myeloid leukemia (AML) at extramedullary sites. While extramedullary involvement in AML is uncommon in itself, isolated myeloid sarcomas, that is, myeloid sarcomas without any bone marrow involvement, are extremely rare and pose a diagnostic and therapeutic challenge. Here, we present the case of a middle-aged woman with isola...

Primary intimal sarcomas are uncommon and highly lethal tumors arising in the mesenchymal tissue of great arteries [1-3]. In this setting, primary Pulmonary Artery Sarcomas (PAS) are often misdiagnosed with a poor prognosis due to their extreme aggressiveness [1-3]. Conversely, Lynch Syndrome is an inherited disorder with an increased risk of developing colorectal cancer, and a well defined spe...

INTRODUCTION Synovial sarcomas are rare malignant tumors of soft tissues, arising mainly from periarticular structures. Gastrointestinal localizations are unusual presentation of these rare sarcomas. METHODS We present the case of a 56- years old man with monophasic synovial sarcoma, arising primarily from the ileum, and causing intussusception. A review of the literature was conducted to gat...