The aim of this study was to determine the clinical and endoscopic manifestations, and pathological characteristics of intestinal schistosomiasis in China, in order to raise awareness of intestinal schistosomiasis and prevent misdiagnosis and missed diagnosis. The retrospective analysis of clinical and endoscopic manifestations, and histopathological characteristics, were conducted for 96 patie...

BACKGROUND Colorectal cancer associated with chronic intestinal schistosomiasis has been linked with the chronic inflammation as a result of schistosomal ova deposition in the submucosal layer of the intestine. Among all species Schistosoma japonicum has been more linked to development of colorectal cancer as compared to Schistosoma mansoni due to absence of population-based studies to support ...

Schistosomiasis, caused by three principal species of diecious trematodes (flatworms), currently afflicts over 250 million individuals, results in an estimated 2-15% chronic disability, and contributes to poor health and economic stagnation in endemic areas. Although schistosomiasis is effectively treated with praziquantel, rapid reinfection with rebound morbidity precludes effective control ba...

Schistosomiasis is a debilitating parasitic disease caused by platyhelminthes of the genus Schistosoma, notably Schistosoma mansoni, Schistosoma haematobium, and Schistosoma japonicum. Pioneer researchers used radiation-attenuated (RA) schistosome larvae to immunize laboratory rodent and non-human primate hosts. Significant and reproducible reduction in challenge worm burden varying from 30% to...

OBJECTIVE To estimate the age-specific disability weight of chronic schistosomiasis japonica in China. METHODS Between October 2004 and January 2005, residents from two schistosome-endemic counties were screened for Schistosoma japonicum infection using an enzyme-linked immunosorbent assay. Disability and morbidity were assessed in seropositive individuals using the European quality of life q...

Article history: Received 2 November 2016 Accepted 2 November 2016 Available online 8 November 2016 and development has become an intense area of research (Zhu et al., 2014), the role of host miRNAs in shaping immune responses against these parasites has been poorly characterized. In a previous study He and coworkers performed a miRNA microarray on livers from S. japonicum-infected mice and ide...

The GST antigen (called 26-28 kDa antigen) extracted and purified from Schistosoma japonicum adult worms was applied to the detection of specific antibodies in sera of infected mice and mice immunized with the above protein antigen by ELISA technique. The 26-28 kDa antigen was better than crude antigens (SEA, SWAP) when used to detect specific antibodies in sera from immunized mice. As with cru...

Schistosomiasis is a chronic helminth disease of humans, linked persistently with poverty. Parasite transmission is reliant on poor sanitation for transmission from humans to the molluscan intermediate host [1,2]. Recent estimates of the global disease burden for schistosomiasis indicate that some 207 million people are infected, with over 750 million people at risk [2]. New control strategies ...

A 32 year-old white man, on his return from working in Nigeria, came for an examination of 3 weeks dry cough associated with fever and asthenia . He used to swim in fresh water in the Niger River valley for 6 months. There was no evidence of malaria. Hypereosinophilia at 18.8% was found in the blood (white blood cell [WBC] = 8,399/mm 3 , eosinophils cells = 1,579/mm 3 ) and in broncho-alveolar ...

A study of liver and colon cancers and their association with a previous diagnosis of schistosomiasis was performed in rural Sichuan, China. The data analysed came from 127 liver-cancer and 142 colon-cancer patients, each matched, by age, gender, hospital and township, with one or two controls. The cancer cases were identified from the hospital records of three Sichuan counties (all of which ha...