Electroconvulsive therapy (ECT) is the most effective treatment for severe major depressive episodes (MDE). Nonetheless, firmly established associations between ECT outcomes and biological variables are currently lacking. Polygenic risk scores (PRSs) carry clinical potential but with response in psychiatry seldom reported. Here, we examined whether PRSs disorder, schizophrenia, cross-disorder, ...

Although body dysmorphic disorder is a psychiatric disorder in its own right, rarely it can be a variant of a variety of psychiatric syndromes like schizophrenia, mood disorders, OCD etc. Following is an unusual case report of a female patient who presented with body dysmorphic disorder later diagnosed as having schizophrenia.

Disruption of visual percepts by a subsequent stimulus (ie, backward masking) has been consistently noted in schizophrenia, with some evidence that this fragility in early perception is present in people with genetic liability for the disorder. Given the potential of backward masking paradigms to mark neural processes that confer risk for schizophrenia, it is important to test the diagnostic sp...

Delusional paranoia has been associated with severe mental illness for over a century. Kraepelin introduced a disorder called "paranoid depression," but "paranoid" became linked to schizophrenia, not to mood disorders. Paranoid remains the most common subtype of schizophrenia, but some of these cases, as Kraepelin initially implied, may be unrecognized psychotic mood disorders, so the relations...

Autism spectrum disorder and schizophrenia share a substantial number of etiologic and phenotypic characteristics. Still, no direct comparison of both disorders has been performed to identify differences and commonalities in brain structure. In this voxel based morphometry study, 34 patients with autism spectrum disorder, 21 patients with schizophrenia and 26 typically developed control subject...

BACKGROUND There has been much literature on schizophrenia, but very little is known about the characteristics of suicides with schizophrenia in comparison with the suicides with other diagnosed psychiatric disorders and without psychiatric disorders. METHODS Thirty-eight suicides with schizophrenia, 150 suicides with other psychiatric disorder, and 204 suicides without a psychiatric disorder...

OBJECTIVE We examined whether established metabolic risk genetic variants in the population confer a risk for increased waist circumference in patients with schizophrenia spectrum disorders and also an association with schizophrenia spectrum disorders irrespective of waist circumference. PATIENTS AND METHODS We analyzed the association in (i) a case-case model in which patients with schizophr...

Schizophrenia occurs in 1% of the population and is severely impairing to those afflicted. Thereby, it utmost importance recognize treat disorder as early possible. For last several decades research has attempted elucidate a variety predictive factors order aid identification patients at high risk developing schizophrenia spectrum disorder. These have included premorbid or prodromal movement sy...

BACKGROUND There is evidence of a link between schizophrenia and a deficit of working memory, but this has been derived from tasks not specifically developed to probe working memory per se. Our aim was to investigate whether working memory deficits may be detected across different paradigms using the self-ordered pointing task (SOPT) and the visual conditional associative learning task (VCALT) ...