β-thalassemias are monogenic disorders characterized by defective synthesis of the β-globin chain, one of the major components of adult hemoglobin. A large number of mutations in the β-globin gene or its regulatory elements have been associated with β-thalassemias. Due to the complexity of the regulation of the β-globin gene and the role of red cells in many physiological processes, patients ca...

The Sixth BHD Symposium and First International Upstate Kidney Cancer Symposium concluded in September 2015, in Syracuse, NY, USA. The program highlighted recent findings in a variety of areas, including drug development, therapeutics and surgical management of patients with BHD and multi-focal renal tumors, as well as multidisciplinary approaches for patients with localized, locally advanced a...

The biographies of 280 scientists demonstrate that the age distribution of their career peaks is identical to those of jazz musicians, painters, and writers, and that this universal age profile holds only among scientists who were married some time in their lives. I interpret this as support for Miller's cultural display model in an evolutionarily novel environment.

The scientific construction of chronic Chagas heart disease (CCHD) started in 1910 when Carlos Chagas highlighted the presence of cardiac arrhythmia during physical examination of patients with chronic Chagas disease, and described a case of heart failure associated with myocardial inflammation and nests of parasites at autopsy. He described sudden cardiac death associated with arrhythmias in 1...

We propose an Artificial Intelligence architecture dedicated to the reconstruction of old scientific discoveries. This architecture is based on the notion “core models” upon which the system draws out the logical consequences of scientific hypotheses. “Core models” are based on an initial ontology that contains entities and concepts recognized by scientists. Hypotheses are tentative explanation...

In this study, Barber's [(1961). Resistance by scientists to scientific discovery. Science, 134, 596-602] analysis of scientists' resistance to discoveries is examined in relation to an 18-year controversy between the dominant cognitive-behavioral paradigm or zeitgeist and its chief rival - eye movement desensitization and reprocessing (EMDR) in treating trauma-related disorders. Reasons for pe...

New scientific knowledge sometimes remains underutilized as compared to its technological potential. We examine two views of the process of science-based invention at the level of the knowledge-producing organization. In one, widespread access to the new scientific knowledge is crucial, and the academic environment therefore fosters invention. In the other, control is paramount and scientific r...