In a recent issue of Critical Care, Qiao and colleagues showed in a rat model of sepsis that dexmedetomidine and midazolam suppress the generation of pro-inflammatory mediators but the effects vary between agents. While dexmedetomidine limited apoptosis to a greater extent than midazolam, both agents significantly reduced short-term mortality compared with saline. This study, in addition to tho...

background: coriandrum sativum l. has been recommended for relief of insomnia in iranian traditional medicine. however, no pharmacological studies have yet evaluated its sedative effects. the aim of this study was to determine if extracts and essential oil of coriander seeds have sedative-hypnotic activity.   methods: the aqueous or hydro-alcoholic extracts or essential oil of coriander seeds (...

• Objective: To assess the impact of daily interruption of sedative infusions on duration of mechanical ventilation and length of stay (LOS) in patients receiving either midazolam and morphine or propofol and morphine. • Design: Randomized controlled trial. • Setting and participants: 128 mechanically ventilated adult patients receiving continuous sedative infusions in a medical intensive care ...

A randomised, double-blind trial of atropine, atropine plus papaveretum, and atropine plus diazepam given intramuscularly as premedication for fibreoptic bronchoscopy in 60 patients showed no difference between the three regimens as assessed by bronchoscopist or patient. Bronchoscopists frequently attributed a sedative action to atropine alone and their assessment of tolerance and sedation was ...

use of new agencies) the different actions attributed to ipecacuanha in its power over dysentery may be curiously mentioned. Dr. Low of Madras, who took the remedy himself, endeavours to account for its good effects by its sedative action on the system of sympathetic nerves, whereby an antiperistaltic action of the intestines is effected and irritation quelled, while it specially influences the...

Patients with schizophrenia often suffer from sleep disturbances such as excessive sleeping and insomnia. Common medications for schizophrenia can have a sedative effect on patients. Not all antipsychotic medications have the same sedative effect, which is related to dosage and affinity for histamine H1 receptors. Studies have shown that, compared with conventional antipsychotics, atypical anti...

Four new pentacyclic benzodiazepine derivatives (PBDTs 13-16) were synthesized by conventional thermal heating and microwave-assisted intramolecular cyclocondensation. Their anticonvulsant, sedative and anxiolytic activities were evaluated by drug-induced convulsion models, a pentobarbital-induced hypnotic model and an elevated plus maze in mice. PBDT 13, a triazolopyrrolo[2,1-c][1,4]benzodiaze...

INTRODUCTION Muscle rigidity and generalized spasm can cause severe pain in patients with tetanus. Administration of high dose sedative or narcotic agents can increase respiratory failure and prolong mechanical ventilation support. CASE PRESENTATION In this report, ultrasound-guided sciatic nerve block was performed in a 25-year-old patient with tetanus to progress his respiratory drive which...

Despite the universal prescription of sedative drugs in the intensive care unit (ICU), current practice is not guided by high-level evidence. Landmark sedation trials have made significant contributions to our understanding of the problems associated with ICU sedation and have promoted changes to current practice. We identified challenges and limitations of clinical trials which reduced the gen...