The provocative effects of sleep deprivation (SD) on patients with seizure disorder and on the electroencephalogram (EEG ) are well known. The purpose of the study was to test its routine use and usefulness in the pediatric and adolescent age group with, or suspect of having, seizure disorder, especially those presenting with first unprovoked seizure. Between September 2000 and November 20...

Epilepsy and antitumor treatment 2) Seizure outcome after radiotherapy and chemotherapy in glioma patients and its relation with radiological response: a systematic review 3) Seizure reduction in a low-grade glioma: more than a beneficial side effect of temozolomide 4) Seizure reduction is a prognostic marker in low-grade glioma patients treated with temozolomide 5) Withdrawal of antiepileptic ...

BACKGROUND AND PURPOSE To investigate the duration of seizures and its relationship to seizure type, epilepsy syndrome, and seizure clustering. METHODS We examined 1,251 seizures from 152 patients who underwent video-electrocorticographic monitoring with subdural electrodes. Their seizure duration, seizure types, epilepsy syndromes, and seizure clusters were analyzed. RESULTS The median sei...

We investigated whether there is a cluster effect depending on localization of seizure foci in patients with bilateral seizure foci. We evaluated 171 seizure pairs from 193 seizures recorded in 28 patients. Seizure lateralization was determined by the lateralization of ictal discharges; if the ictal EEG pattern was not lateralized, lateralization was determined by clinical seizure semiology. Th...

Seizure activity has been proposed to result in the generation of reactive oxygen species (ROS), which then contribute to seizure-induced neuronal damage and eventually cell death. Although the mechanisms of seizure-induced ROS generation are unclear, mitochondria and cellular calcium overload have been proposed to have a crucial role. We aim to determine the sources of seizure-induced ROS and ...

 ABSTRACT Background: The efficacy of anticonvulsants after a first seizure is uncertain the more predictable the time and the type of recunent seizure, the more preventable the probable events. This study was conducted to evaluate sirnilmity of type and time of a first seizure and its recutTence in children. Methods: 174 children with at least two separate seizures were taken into account. Res...

OBJECTIVES To develop prognostic models for risk of a breakthrough seizure, risk of seizure recurrence after a breakthrough seizure, and likelihood of achieving 12-month remission following a breakthrough seizure. A breakthrough seizure is one that occurs following at least 12 months remission whilst on treatment. METHODS We analysed data from the SANAD study. This long-term randomised trial ...