White-Coat and Masked Hypertension: Selective Elevation of Blood Pressure or an Arbitrarily Partitioned Continuum? To the Editor: Data from the Pressioni Arteriosc Monitorate e Loro Associazioni (PAMELA) study, presented by Mancia et al,1 are invaluable for understanding the true nature of white-coat and masked hypertension. Thus, in terms of long-term risk, the authors’ conclusions that these ...

BACKGROUND/AIM Endothelin-1 plays an important role in the regulation of portal hypertension; endothelin antagonists have been extensively studied in portal hypertensive animals. We aimed to evaluate the efficacy of highly selective endothelin antagonists in partial portal vein ligated (PPVL) rats. METHODS Four groups of 7 male Sprague-Dawley rats were administered orally ABT-627 (ET(A)-selec...

The effect of dietary NaCl on blood pressure has generally been attributed to the sodium ion. However, recent evidence indicates that the anion accompanying sodium plays an important role in determining the magnitude of the blood pressure increase in response to a high dietary intake of NaCl. The purpose of this review is to describe studies of blood pressure responses in several experimental m...

The response to uniform selection may occur in alternate ways that result in similar performance. We tested for multiple adaptive solutions during artificial selection for high voluntary wheel running in laboratory mice. At generation 43, the four replicate high runner (HR) lines averaged 2.85-fold more revolutions per day as compared with four non-selected control (C) lines, and females ran 1....

We study numerically a stochastic mortel for evolution and maintenance of a population which reproduces asexually under selective pressure and is divided into smaller

Purpose: To evaluate the effect of selective laser trabeculoplasty in the treatment of patients with glaucomatocyclitic crisis. Methods: This was a retrospective case series study. 10 patients with uncontrolled intraocular pressure using maximally tolerated medical treatment were included in our study. 360o selective laser trabeculoplasty was performed during the intermission of glaucomatocycli...

To examine the regional mechanical effects of selective genioglossus muscle activation on pharyngeal airway size and function, magnetic resonance images of the pharyngeal airway were obtained in five paralyzed, anesthetized cats over a range of positive and negative pressures in an isolated, sealed upper airway. When all results across pressure levels and pharyngeal regions were analyzed, genio...