In order to evaluate the anti-mutagenic effects of the potential chemoprotective compounds selenium and (S)-2-(3-aminopropylamino)ethylphosphorothioic acid (WR-1065), CHO AA8 cells were exposed to both compounds either individually or in combination prior to irradiation. Mutation frequency following exposure to 8 Gy was evaluated by quantitation of the mutations detected at the hprt locus of th...

We conducted in vitro and in vivo assays in a selenium-deficient system to determine if organic matter (mainly fulvic acid; FA) is involved in a free radical mechanism of action for Kashin-Beck disease. Cartilage cell culture experiments indicated that the oxy or hydroxy functional groups in FA may interfere with the cell membrane and result in enhancement of lipid peroxidation. Experiments wit...

The accumulation of cadmium in plants produces phytotoxic damage and a decrease crop yield. To avoid this effect, it is necessary to prevent its absorption by roots reduce toxicity plant tissues. current study was aimed evaluate the effect exogenous applications Biocat G (fulvic/humic acids), selenium (Se), chitosan leaves broccoli exposed Cd stress. applied treatments were: (i) T1: Hoagland nu...

I n retrospect, the history of selenium biochemistry does not differ greatly from the study of a number of other trace elements in that it occurred over many years, progressing from periods of little general interest to widespread concern regarding toxicity problems and eventually to recognition of selenium as an essential nutrient for many forms of life. My involvement in studies on selenium m...

BACKGROUND Investigate alterations in the expression and localization of carbohydrate units in rat retinal cells exposed to cisplatin toxicity. AIMS The aim of the study was to evaluate putative protective effects of selenium on retinal cells subjected to cisplatin. STUDY DESIGN Animal experiment. METHODS Eighteen healthy Wistar rats were divided into three equal groups: 1. Control, 2. Ci...

Selenium nanoparticles (SeNPs), as a special form of selenium (Se) supplement, have attracted worldwide attention due to their favorable properties and unique bioactivities. Herein, an eco-friendly and economic way to prepare stable SeNPs is introduced. SeNPs were synthesized in aqueous chitosan (CTS) and then embedded into CTS microspheres by spray-drying, forming selenium nanoparticles-loaded...

George Santayana, the Spanish philosopher, is credited with the often paraphrased quote that " those who cannot remember the past are condemned to repeat it. " In our most cynical moments, these words ring true as a commentary on micro-nutrient supplements for cancer prevention. Four years ago, Tim Byers (1) eloquently summarized in an editorial titled " Anticancer Vitamins du Jour: The ABCED's...

Dietary selenium (Se) is an essential micronutrient that exerts its biological effects through its incorporation into selenoproteins. This family of proteins contains several antioxidant enzymes such as the glutathione peroxidases, redox-regulating enzymes such as thioredoxin reductases, a methionine sulfoxide reductase, and others. In this review, we summarise the current understanding of the ...

BACKGROUND Selenium is an essential trace element that also elicits toxic effects at modest intakes. Investigations of selenium metabolites in urine can help our understanding of the transformations taking place in the body that produce these beneficial and detrimental effects. There is, however, considerable discord in the scientific literature regarding the selenium metabolites thought to pla...