Dissolution testing of the drug formulation introduced in 1960 since then the importance of dissolution test has grown rapidly as have the number of tests and demands in quality control laboratories. Dissolution testing is an official test used by pharmacopeias for evaluating drug release of solid and semisolid dosage forms. The main applications of the dissolution testing include biopharmaceut...

The objectives of the present work were, first, to develop a self-nanoemulsified drug delivery system (SNEDDS) based on the eutectic properties of ubiquinone (CoQ10); and second, to study the progress of emulsion formation and drug release mechanisms by turbidimetry and droplet size analysis. Binary phase diagrams of CoQ10 with menthol and essential oils were constructed and used to develop the...

Metal casting is an industrially important manufacturing process offering a superior combination of design flexibility, productivity and cost-effectiveness, but has limitations due to filling related defects. Several semisolid processes are available capable at range solid fractions overcome this. The current communication aims review the front behaviour give new perspective gate in processing ...

Sensitive and reproducible methods to assess in vitro release rates from semisolid products can provide significant value during drug development. The purpose of the present study was to develop and validate an in vitro release test (IVRT) for a topical gel formulation of an HIV microbicide. The method was developed using a vertical diffusion cell system, commercially available synthetic membra...

Current practice in designing tooling components for semisolid processing requires extensive commitments of human resources. Even when utilizing currently available Computer Aided Design (CAD) systems, tool design remains a complex task requiring large amount of design knowledge. Considerations such as part material, tool material, characteristics of die filling, flow behavior of semisolid slur...

Coccidioides immitis appears to be unable to digest particulate collagen when cultured on collagen-containing semisolid culture media. However, all C. immitis strains solubilized collagen when the fungus was grown in liquid suspension cultures. Moreover, sterile culture filtrates were collagenolytic in collagen-buffer-agar plate assays.