In a randomized clinical trial, study participants are assigned to various treatment arms through randomization. This random allocation of participants to treatment arms decreases bias and controls for numerous confounders (1). A common type of randomization is simple randomization, where each participant is randomly assigned to a treatment arm with a known (usually equal) probability, regardle...

Bacteriophage T7 helicase (T7 gene 4 helicase-primase) is a prototypical member of the ring-shaped family of helicases, whose structure and biochemical mechanisms have been studied in detail. T7 helicase assembles into a homohexameric ring that binds single-stranded DNA in its central channel. Using RecA-type nucleotide binding and sensing motifs, T7 helicase binds and hydrolyzes several NTPs, ...

Bacteriophage T7 gene 2.5 protein has been shown to interact with T7 DNA polymerase (the complex of T7 gene 5 protein and Escherichia coli thioredoxin) by affinity chromatography and fluorescence emission anisotropy. T7 DNA polymerase binds specifically to a resin coupled to gene 2.5 protein and elutes from the resin when the ionic strength of the buffer is raised to 250 mM NaCl. In contrast, T...

We propose a formal model for security of verifiable shuffles and a new efficient verifiable shuffle system based on the Paillier encryption scheme, and prove its security in the proposed model. The model is general, so it can be extended to verifiable shuffle decryption and provides a direction for provable security of mix-nets.

This paper proposes an arrayed-waveguide grating (AWG) based wavelength-divisionmultiplexing (WDM) shuffle network. Compared with previous optical shuffle networks, our proposal is compact, easy to implement, highly scalable, and cost effective. OCIS codes: (060.4258) Networks, network topology; (060.4265) Networks, wavelength routing

Exploring how biological systems have been 'designed' by evolution to achieve robust behaviours is now a subject of increasing research effort. Yet, it still remains unclear how environmental factors may contribute to this process. This issue is addressed by employing a detailed computer model for the intracellular growth of phage T7. More than 150 000 in silico T7 mutants were generated and th...

We extend a word language concept called shuffle ideal to general algebras. For this purpose, we introduce the relation SH and show that there exists a natural connection between this relation and the homeomorphic embedding order on trees. We establish connections between shuffle ideals, monotonically ordered algebras and automata, and piecewise testable tree languages.

We show that the class of distributed time-asynchronous automata is more expressive than timed automata, has a decidable emptiness problem, is closed under union, concatenation, star, shuffle and renaming, but not under intersection. The closure results are obtained by showing that distributed time-asynchronous automata are equivalent with a subclass of shuffle regular expressions and its relat...