Biomechanical Signaling Physarum polycephalum, a slime mold with one cell and no brain, is remarkable new model for understanding basal cognition. Its living material deforms its own structure to interact the objects around it. In article number 2008161, Michael Levin co-workers show that senses strain in substrate, using biomechanical signaling assess environment express preferences as directi...

objective(s):degradation of sphingosine 1-phosphate (s1p), as a bioactive lipid, or deregulation of its production involves in tumor progression, metastasis and chemoresistance. since the tumor progression effects of s1p and its mechanism in chronic lymphoblastic leukemia and non-small cell lung cancer is not fully understood, we investigated the role and one of the mechanisms of s1p in tumor p...

signal transducers and activators of transcription (stats) are cytoplasmic transcription factors that have a key role in cell fate. stats, a protein family comprised of seven members, are proteins which are latent cytoplasmic transcription factors that convey signals from the cell surface to the nucleus through activation by cytokines and growth factors. the signaling pathways have diverse biol...

inflammation serves a protective function in controlling infections and promoting tissue repair, and can also cause damage to tissue and disease. many types of cells involved in this process, expressing the components of the cannabinoid signaling system that can be controlled endogenously or pharmacologically. cannabinoids inhibit neuroinflammation and the immune cells express the whole machine...

plants face many biotic and abiotic stresses at the same time during their growth under field conditions. plants responses toward combined stresses are often more complex than their responses to one type of stress in a way that the results of these responses are called as cross tolerance. this mixture of stresses activates specific models of gene expression that causes special signaling network...

objective: creb1 is an important downstream protein for many signaling pathways. by designing efficient sirnas against creb1, it may be possible to assess the role of molecules involved in signaling pathways in different cell types. in this research the efficiency of creb1 knockdown by two different sirnas in k562 cells has been studied. materials and methods: sirnas have been designed accordi...