The focus of this research was to develop a better understanding of the pertinent physico-chemical properties of silver nanoparticles (AgNPs) that affect genotoxicity, specifically how cellular uptake influences a genotoxic cell response. The genotoxicity of AgNPs was assessed for three potential mechanisms: mutagenicity, clastogenicity and DNA strand-break-based DNA damage. Mutagenicity (rever...

We found that silver, either as silver metal or silver chloride, exerted toxic effects on the smooth muscle of isolated cannulated hamster cheek pouch arterioles. Silver initially stimulated the smooth muscle, producing a marked vasoconstriction. The vessels then dilated back to control diameters. Once the arterioles began to dilate, they became refractory to norepinephrine or potassium stimula...

We report the green synthesis of silver nanoparticles by using Euphorbia condylocarpa M. bieb root extract for the synthesis of N-monosubstituted ureas in water. UV-visible studies show the absorption band at 420 nm due to surface plasmon resonance (SPR) of the silver nanoparticles. This reveals the reduction of silver ions (Ag+) to silver (Ago) which indicates the formation of silver nanoparti...

Silver nanoparticles were synthesized using Cynodon dactylon leaf extract and this study demonstrates the efficacy of biologically synthesized Silver nanoparticles (AgNPs) as anticancer and antibacterial agent. Anticancer activity of the biologically synthesized silver nanoparticles was studied using HEpG-2 cell line. The AgNPs showed dose-dependent cytotoxicity against HEpG-2 cells. Antimicrob...

The role of silver and sulfadiazine in the mechanism of action of silver sulfadiazine on burn wound infections was investigated. Silver, but not sulfadiazine, was bound by bacteria. Sulfadiazine did not act as an antibacterial agent in low concentrations, but exhibited specific synergism in combination with subinhibitory levels of silver sulfadiazine. The efficacy of silver sulfadiazine is thou...

Silver is considered as antibacterial agent with well-known mode of action and bacterial resistance against it is well described. The development of nanotechnology provided different methods for the modification of the chemical and physical structure of silver, which may increase its antibacterial potential. The physico-chemical properties of silver nanoparticles and their interaction with livi...

A novel electrode modified with silver nanoparticles was fabricated. It is found that the reducibility of silver nanoparticles is higher than for bulk silver by comparing a silver nanoparticles modified electrode with a silver micro-disk electrode. When SCN was added, a new oxidation peak occurred and the anodic peak current of silver nanoparticles decreased. The new anodic peak current is prop...

NTRODUCTION Silver is well known as an antiseptic agent (silver nitrate and silver sulphadiazine) for ages. However, the delivery system in the form of a salt has been a limiting factor for its successful and widespread biological use. The development of nanochemistry has produced micro fine particles which increase silver's solubility and releases silver ions in concentration of 70-100 ppm. Na...

Chitosan–silver (CS–Ag) nanocomposite materials were synthesized by a simple chemical method. The synthesized CS–Ag nanocomposite contains 20 wt% silver. Silver nanoparticles were synthesized by chemical reduction method as well. The CS–Ag nanocomposite was characterized using Field emission scanning electronic microscope (FESEM), X-ray diffraction (XRD) and Fourier transform infrared spectrosc...

Self-assembled particles of genetically engineered human L subunit ferritin expressing a silver-binding peptide were used as nanocontainers for the synthesis of silver nanoparticles. The inner cavity of the self-assembled protein cage displays a dodecapeptide that is capable of reducing silver ions to metallic silver. This chimeric protein cage when incubated in the presence of silver nitrate e...