We describe a methodology for simulating student behavior to predict the effects of skill-learning parameter changes on system behavior. Validation against data collected after the changes were made shows that accurate predictions can be made despite a different cohort of students. Furthermore, deviations from the predictions may help explain unexpected effects of other changes made to the tuto...

This paper presents a simulator tool that can simulate large databases of visually realistic longitudinal MRIs with known volume changes. The simulator is based on a previously proposed biophysical model of brain deformation due to atrophy in AD. In this work, we propose a novel way of reproducing realistic intensity variation in longitudinal brain MRIs, which is inspired by an approach used fo...

When simulating very large, biologically plausible models on desktop computers, the memory bandwidth is the biggest bottleneck due to the significant performance difference between memory and processor. We did the performance analysis for different variations of the Palm association network implemented on Pentium 4 with VTune 6.1 Performance Analyzer. We also analyzed the performance of an FPGA...

Recently, we obtained the first prove that the pharmacological modulation of a clock-related protein is a suitable strategy for the identification of innovative anticancer approaches [6]. Although it is wide recognized that cancer cells and normal cells do not share a common clock, the molecular basis of this difference is still unclear. We discovered an unpredicted cancer-specific “paralog swi...

With the emergence of chemical biology, the use of pharmacological inhibitors in biological research has been expanding. SP600125 is a low-molecular weight compound that has been widely used to inhibit c-Jun-N-terminal kinase (JNK). A recent publication by Tanemura et al. (J. Biochem. 145:345-354, 2009) indicated that SP600125 also inhibits phosphatidylinositol 3-kinase (PI3K) in an isoform-sel...