CYP2C19 polymorphism is associated with pretreatment drug response prediction, metabolism, and disposition. Pakistan consists of a population comprising of various ethnic groups residing in different regions of the country each claiming diverse ethnic origins. The identification of CYP450 genotypic composition of these populations is therefore necessary to avoid adverse drug reactions in these ...

CYP2C19 polymorphism is associated with pretreatment drug response prediction, metabolism, and disposition. Pakistan consists of a population comprising of various ethnic groups residing in different regions of the country each claiming diverse ethnic origins. The identification of CYP450 genotypic composition of these populations is therefore necessary to avoid adverse drug reactions in these ...

BACKGROUND Knowledge is an important pre-requisite for implementing both primary as well as secondary preventive strategies for cardiovascular disease (CVD). There are no estimates of the level of knowledge of risk factor of heart disease in patients with CVD. We estimated the level of knowledge of modifiable risk factors and determined the factors associated with good level of knowledge among ...

Retrospective study in different ethnic groups determines the burden and patterns of breast cancers during the last eight years reported in Oncology wards of hospitals of Karachi, Pakistan and compares the pharmacotherapy/chemotherapy used with international guidelines, develops strategies for screening and evidence based pharmacotherapy/chemotherapy of cases. Every single one male & female cas...

Objectives Early detection is of crucial importance for prevention type 2 diabetes and pre-diabetes. Diagnosis these conditions relies on the oral glucose tolerance test haemoglobin A1c estimation which are invasive challenging large-scale screening. We aimed to combine non-invasive nature ECG with power machine learning detect Methods Data this study come from Diabetes in Sindhi Families Nagpu...

TOPIC: Diffuse Lung Disease TYPE: Original Investigations PURPOSE: Idiopathic Pulmonary Fibrosis (IPF) is considered a disease of unknown etiology with varying incidence among populations and geographies. This study aimed to assess the risk factors IPF Pakistani population. METHODS: A gender age matched case-control was conducted. Adult cases IPF, were defined on criteria by Indian Chest Regist...

Introduction Renal transplantation is the definitive treatment for end stage renal disease. Patients subjected to transplantation require lifelong immunosuppression and are prone to several gastrointestinal disorders. Dyspepsia is a common disorder in these patients. The objective of this study was to determine factors leading to dyspepsia in renal (kidney) transplant recipients. Methods It w...

Daily milk records of 88 cows in a multibreed dairy herd were used to describe lactation curves and test the ability of seven models to predict daily milk yields, and accumulated 100-d and 305-d milk yields. The seven mathematical models were a gamma function, a mixed log second-degree polynomial model, and five polynomial regression models. Cows were of three breed groups: Holstein Friesian (H...

The aim of this study was to assess the usefulness of ultrasonographic examination of the large intestine in 10 clinically healthy Jersey/Red Sindhi crossbred cows. The area extending from the tuber coxae to the 6th intercostal space (ICS) and from the lumbar transverse processes to the linea alba on the right side was shaved. An imaginary line was drawn from the distal third of the femur up to...

The experiment was carried out using fistulated multiparous Holstein Friesian crossbred (75% Holstein Friesian and 25% Red Sindhi) dairy cows in their dry period fed on untreated rice straw to evaluate the nutritive value of local protein feed resources using the in sacco method and in vitro pepsin-pancreatin digestion. Experimental feeds were cottonseed meal (CSM); soybean meal (SBM); dried br...