Purpose:Conventional anticancer treatments are often impaired by thepresenceofhypoxia. TH-302selectively targetshypoxic tumor regions, where it is converted into a cytotoxic agent. This study assessed the efficacy of the combination treatment of TH-302 and radiotherapy in two preclinical tumor models. The effect of oxygen modification on the combination treatment was evaluated and the effect of...

The C(4)-Pdk gene encoding the C(4) enzyme pyruvate, orthophosphate dikinase (PPDK) of maize (Zea mays cv Golden Cross Bantam) was introduced into the C(3) plant, rice (Oryza sativa cv Kitaake). When the intact maize C(4)-Pdk gene, containing its own promoter and terminator sequences and exon/intron structure, was introduced, the PPDK activity in the leaves of some transgenic lines was greatly ...

Spatially isolating genetically modified (GM) maize fields from non-GM maize fields is a robust on-farm measure to keep the adventitious presence of GM material in the harvest of neighboring fields due to cross-fertilizations below the European labeling threshold of 0.9%. However, the implementation of mandatory and rigid isolation perimeters can affect the farmers' freedom of choice to grow GM...

This case examines the business development and strategic expansion of Greenway Medical Technologies, a software company delivering electronic healthcare solutions to physicians operating small practices. Over a period of seven years and with an investment of $70 million, Greenway built a best-in-class software application. The case also describes the electronic medical record systems industry ...

I t has recently been observed that many weeks after injection of small amounts of antigen, removal of ant ibody from the circulation results in a specific, secondary-type, ant ibody response (1, 2). This observation suggests that a dynamic equilibrium between persisting immunogen and circulating antibody regulates the immune response (3), and further, that immunocompetent cells can capture ant...

Icariin is recognized as the major bioactive component of Herba Epimedii. The aim of this study was to evaluate the anti-fatigue properties of icariin using a weight-loaded forced swimming test. The mice were randomly divided into four groups, a control group and three icariin treatment groups. The icariin treated groups received different doses of icariin per os (100, 200 and 400 mg/kg of body...

Vastus medialis muscle of a 52-year-old male professional weight-lifter (master degree) was ruptured during training. After 3 days, he (HG.,D. Height: 179 cm, Weight: 98 kg) was admitted to sports medicine clinic with oedema, pain, and swelling on the medial side of his right knee (dominant side). After the physical examination and MRI assessment, nearly total vastus medialis rupture was detect...

The level of stem cell proliferation must be tightly controlled for proper development and tissue homeostasis. Multiple levels of gene regulation are often employed to regulate stem cell proliferation to ensure that the amount of proliferation is aligned with the needs of the tissue. Herewe focus on proteasome-mediated protein degradation as ameansof regulating the activities of proteins involv...

From August 1999 through July 2002, hyperinvasive Neisseria meningitidis serogroup B (MenB) clonal complexes (CCs), namely, ST-32/ET-5 (CC32) and ST-41/44/lineage 3 (CC41/44), were predominant in the Western Cape Province of South Africa. This study analyzed MenB invasive isolates from a national laboratory-based surveillance system that were collected from January 2002 through December 2006....

in arid, semiarid, and mediterranean climates, particularly in west asia and north africa, farmers face limited water resources and must develop irrigation management methods to increase crop production while reducing water use. this study examined methods to reduce irrigation water loss and increase maize water productivity at safiabad agricultural research center in dezful, iran in 2007 and 2...