In 23 patients (ages 44 to 81) presenting with syncope, vertigo, or transient amnesia, carotid sinus massage produced a significant bradycardia in association with symptoms. The 10 most severely symptomatic patients were studied electrophysiologically, including measurement of intracardiac conduction times and corrected sinus node recovery times, as well as with carotid sinus massage before and...

During segmental isolation of the pulmonary veins (PVs) in a patient with paroxysmal atrial fibrillation, there was a PV bradycardia that was dissociated from the left atrium in a segment of the right superior PV, whereas the remaining segments showed passive activation of a PV fascicle during sinus rhythm. Rapid atrial pacing induced a PV tachycardia in the nonisolated fascicles, and the disso...

Background Unlike tachyarrhythmias, which are common in pregnancy, there is a paucity of data regarding maternal bradycardias. Our objective was to describe the characteristics, associated conditions, and prognosis women who develop bradycardia post-partum. Method We conducted retrospective chart review patients referred Obstetrical Medicine service at British Columbia Women's Hospital from Jan...

The sinoatrial node (SAN) contains a small number of pacemaker cells (PCs), specialized cardiomyocytes whose automatic firing triggers each heart beat. Autonomic and endocrine modulation of PC automaticity enables precise neurohormonal regulation of heart rate (HR) in accordance with physiological demand. While the cellular mechanisms that underlie HR regulation are complex and still actively d...

Intelligent computing system and knowledge-based system have been widely used in the diagnosis and classification of ECG based diseases. Several detection methods of ECG parameters for a particular disease have also been reported in the literature. But little effort has been made by researchers to combine both. In this work, an integrated model of rule base system for generating cases and ANN m...

BACKGROUND The sarcoplasmic reticulum Ca(2+)-ATPase (SERCA2) pump is an important component of the Ca(2+)-clock pacemaker mechanism that provides robustness and flexibility to sinus node pacemaking. We have developed transgenic mice with reduced cardiac SERCA2 abundance (Serca2 KO) as a model for investigating SERCA2's role in sinus node pacemaking. METHODS AND RESULTS In Serca2 KO mice, vent...

Rivastigmine transdermal patch is indicated for patients with Alzheimer's disease and dementia with Parkinson's disease. Rivastigmine, an acetylcholinesterase inhibitor, has several common adverse effects, mainly involving the gastrointestinal tract, but few cardiovascular adverse effects have been reported. This report presents two cases of patients presenting with 3(rd) degree atrioventricula...

Rhythms that derive from parts of atria other than the sinus node are called premature atrial contractions (PACs). Vast majority of fetal PACs are idiopathic. Fetal PACs usually have a good prognosis and disappear spontaneously during pregnancy or after delivery. Development of fetal tachycardia or fetal bradycardia is rarely reported during follow-up of fetuses diagnosed with PACs. To the best...

Seventy-four men between the ages of 18 and 39 years (mean age 25.8 years) undergoing gastro-intestinal endoscopy were electrocardiographically monitored in order to ascertain whether significant cardiac arrhythmias occurred during the procedure. Sinus bradycardia was noted in six patients (8-1 per cent) during intubation and ventricular ectopics were noted in one patient. These changes were no...

We present a case of swine flu presenting as bilateral pneumonia with involvement of cardiac conduction system in the form of increased PR interval and sinus bradycardia during the initial course of disease process. To the best of our knowledge, affection of conducting system in a case of swine flu has not been reported in the literature so far.