نتایج جستجو برای: skbr3
تعداد نتایج: 420 فیلتر نتایج به سال:
Aberrant expression or activity of epidermal growth factor receptor (EGFr) or the closely related p185(erbB2) can promote cell proliferation and survival and thereby contribute to tumorigenesis. Specific antibodies and low molecular-weight tyrosine kinase inhibitors of both proteins are in clinical trials for cancer treatment. CP-654577 is a potent inhibitor selective for p185(erbB2), relative ...
Abstract Objectives Breast cancer cell growth and proliferation requires lipids for energy production, membrane synthesis, or as signaling molecules. Lipids can be delivered to cells by lipoprotein lipase (LPL), an extracellular that hydrolyzes triacylglycerols phospholipids from lipoproteins, is expressed adipose tissue some breast lines. Studies have shown hydrolysis products induce pro-infla...
Cardiovascular diseases are the leading causes of death worldwide, closely followed by cancer. To investigate impact breast cancer cell lines (SKBR3, MCF-7, and MDA-MB-231) on endothelial adhesion, a blended medium containing 30% breast-cancer-conditioned was prepared. This then exposed to human umbilical vein cells (HUVECs) monocytes (THP-1) for 48 h. Homemade oxidized low-density lipoproteins...
Differentiation programs are aberrant in cancer cells allowing them to express differentiation markers in addition to their tissue of origin. In the present study, we demonstrate the multi-lineage differentiation potential of breast cancer cell lines to express multiple neuronal/glial lineage-specific markers as well as mammary epithelial and melanocytic-specific markers. Multilineage expressio...
Homeobox A11 (HOXA11) is one of the hypermethylated genes in breast cancer and its function in breast tumorigenesis remains elusive. In this study, we analyzed the methylation status of HOXA11 in 264 paired breast cancer and normal tissue as well as in matched serum samples by MethyLight assay. Further, the function of HOXA11 in breast tumorigenesis was analyzed by cell proliferation and migrat...
Tumor-associated macrophages (TAMs) exist in nearly all tumors, and form a major part of the tumor microenvironment . TAMs are divided into two groups: tumor-suppressing M1 type tumor-promoting M2 type. Most educated by cells to become type, which support growth make immunotherapy ineffective. Antibody-dependent cellular phagocytosis (ADCP) is an important mechanism for antibody cancer therapy,...
We have identified that StarD10, a member of the START protein family, is overexpressed in both mouse and human breast tumors. StarD10 was initially discovered on the basis of its cross-reactivity with a phosphoserine-specific antibody in mammary tumors from Neu/ErbB2 transgenic mice and subsequently isolated from SKBR3 human breast carcinoma cells using a multistep biochemical purification str...
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