Skeletal muscle in vertebrates is derived from somites, epithelial structures of the paraxial mesoderm, yet many unrelated reports describe the occasional appearance of myogenic cells from tissues of nonsomite origin, suggesting either transdifferentiation or the persistence of a multipotent progenitor. Here, we show that clonable skeletal myogenic cells are present in the embryonic dorsal aort...

The skeletal system, comprising bones, ligaments, cartilage and their connective tissues, is critical for the structure and support of the body. Diseases that affect the skeletal system can be difficult to treat, mainly because of the avascular cartilage region. Targeting drugs to the site of action can not only increase efficacy but also reduce toxicity. Bone-targeting drugs are designed with ...

Two cases of pigmentation of the skeletal system due to tetracycline are reported. It is suggested that tetracycline may be stored in bone due to a tetracycline hydrochloride calcium phosphate complex after prolonged tetracycline administration, and that tetracycline may be the antibiotic of choice in certain cases of osteomyelitis. Dark pigmentation of the teeth may be due to prolonged tetracy...

BACKGROUND Skeletal scintigraphy remains a valuable tool in the initial and subsequent evaluation of the skeletal system in patients with a diagnosis of primary or metastatic neoplasms. METHODS We discuss radiopharmaceuticals, nuclear medicine imaging techniques, and current as well as future oncological applications in the adult population. Pertinent literature was reviewed to describe the a...

Osteoporotic fractures are associated with substantial morbidity, increased medical cost and high mortality risk. Several equipments of bone assessment have been developed to identify individuals, especially postmenopausal women, with high risk of osteoporotic fracture; however, a large segment of women with low skeletal bone mineral density (BMD), namely women with high risk of osteoporotic fr...

Skeletal Class III malocclusion treatment is complex, especially when jaw deviations are serious. Camouflage of skeletal improves prognosis with a slight-to-moderate functional shift. This report presents the case 23-year-old male poor facial esthetics associated chin protrusion and an uncomfortable bite. He had concave profile, unfavorable incisor displays, protrusive lower lip, strained lip c...

This work experiments with human motion initiated music generation. Here we present a stand-alone system to tag human motions readily into musical notes. We do this by first discovering the human skeleton using depth images acquired by infrared range sensors and then exploiting the resultant skeletal tracking. This realtime skeletal tracking is done using the videogame console Microsoft KinectT...

Frog skeletal muscle and mammalian heart muscle were studied in vitro before and after glycerol treatment. Loss of contractility, changes in the action potential and disruption of the T system were observed in skeletal muscle cells. In mammalian heart muscle the T system was not disrupted with hypertonic glycerol treatment, and no significant electrophysiological changes were observed. The cont...

Chronic obstructive pulmonary disease (COPD) is a debilitating disease caused by parenchymal damage and irreversible airflow limitation. In addition to lung dysfunction, patients with COPD develop weight loss, malnutrition, poor exercise performance, and skeletal muscle atrophy. The latter has been attributed to an imbalance between muscle protein synthesis and protein degradation. Several repo...

Skeletal muscle is an interesting target for gene therapy. To achieve effective gene introduction in skeletal muscle, a hydrodynamic approach by intravenous injection of plasmid DNA (pDNA) with transient isolation of the limb has attracted attention. In this study, we demonstrated that polyplex nanomicelle, composed of poly(ethyleneglycol) (PEG)-block-polycation and pDNA, showed excellent capac...