BACKGROUND The vitamin D endocrine system, besides multiple other functions, regulates aging in many tissues, including the skin. It protects the skin against the hazardous effects of many skin age-inducing agents, including ultraviolet radiation. Thus, in the present study we aimed to investigate the relationship between facial skin aging and 25-hydroxyvitamin D [25(OH)D] serum levels in healt...

The traditional Indian medicine-Ayurveda, describes various herbs, fats, oils and minerals with anti-aging as well as wound healing properties. With aging, numerous changes occur in skin, including decrease in tissue cell regeneration, decrease in collagen content, loss of skin elasticity and mechanical strength. We prepared five topical anti-aging formulations using cow ghee, flax seed oil, Ph...

background and objectives: this study is the first research on the physiochemical characteristics, microbial population and microstructure of poosti cheese over 90-days of ripening. the main difference between poosti cheese and other types of traditional cheese is the skin, which is used for its storage. materials and methods: physicochemical characteristics including moisture, salt, ph, acidit...

Retinol, an established topical ingredient for improving signs of photo-aging, is often limited in concentration due to the potential low-level visible and sensory irritation. A new anhydrous, 0.5% stabilized retinol serum was developed, balancing bioactivity tolerability. This patented formula uses Relative Polarity Index (RPI) between skin, retinol, emollient ratios, allowing controlled bio-d...

When Overexposure to sun UV radiation leads skin damage and increases the risk of cancer; thus, it is a factor in aging, which accelerate aging cancer. To determine Photoprotective potential was evaluated by biomechanical measurements tissue histopathological examination skin. Showed The group irradiated with exposed for 4 h (UV lamps, wavelength 365 nm, power 6 W) without Aloe vera showed sign...

Skin aging is characterized by different features including wrinkling, atrophy of the dermis and loss of elasticity associated with damage to the extracellular matrix protein elastin. The aim of this study was to investigate the aging process of skin elastin at the molecular level by evaluating the influence of intrinsic (chronological aging) and extrinsic factors (sun exposure) on the morpholo...

Senescent melanocytes accumulate in photoaged skin and are closely related to aging. A better understanding of molecular characteristics senescent might be a key controlling We have developed an vitro model senescence using UV irradiation highlighted that characterized by melanosome transfer dysfunction resulting melanin accumulation. The defective transport was confirmed with ultrastructural c...

Skin aging is a multifactorial process which segmented into two major categories: intrinsic (or chronological aging) and extrinsic (due to external factors). Regardless of the type aging, many mechanisms overlap resulting in loss critical structure due lower production extracellular matrix (ECM) proteins such as collagen well altered content certain glycosaminoglycans (such hyaluronic acid) fun...

The RNA binding protein YBX1 is a key regulator of epidermal progenitor cell senescence that prevents the mRNA translation critical senescence-associated secretory phenotypes (SASP) transcripts such as CXCL1 and IL8. Decreased levels during aging enables production SASP-related proteins subsequent induction senescence. Posttranslational modifications YBX1, phosphorylation at Ser 102, can modify...

“Successful aging” counters the traditional idea of aging as a disease and is increasingly equated with minimizing age signs on skin, face, body. From this stems interest in preventative aesthetic dermatology that might help healthy treat or prevent certain cutaneous disorders, such skin cancer, delay by combining local systemic methods therapy, instrumental devices, invasive procedures. This r...