نتایج جستجو برای: sle
تعداد نتایج: 10032 فیلتر نتایج به سال:
background: systemic lupus erythematosus (sle) is a multisystem autoimmune disease. emerging data suggests that t helper 17 (th17) cells play a pathogenic role in sle and the increased number of these cells correlates with disease activity. in recent years, 1α, 25-dihydroxyvitamin d3 (1,25vitd3) has been considered as an immunomodulatory factor. objective: to investigate the effect of 1,25vitd3...
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by production of numerous autoantibodies and damage to multiple organs and systems. SLE most often affects heart, joints, skin, lungs, blood vessels, liver, and kidneys. SLE is seen in young women of childbearing age (20 – 40 years) but it may occur at any age. Like other autoimmune disorders etiology of SLE is unknown, b...
OBJECTIVE To assess the immunogenicity and safety of influenza vaccine in patients with systemic lupus erythematosus (SLE). METHODS Relevant articles were retrieved from electronic databases. Seroprotection rate, seroconversion rate and factors that increase antibody geometric mean titer (GMT) were used as indices to measure the immunogenicity. The safety of vaccine was assessed through monit...
BACKGROUND Staphylococcus aureus (SA) is a commensal bacterium representing one of the most important components of the skin microbiome, mostly isolated in the anterior nares. A higher rate of SA nasal colonization in patients affected by Wegener's granulomatosis and rheumatoid arthritis compared with healthy subjects (HS) has been described. No studies focusing on systemic lupus erythematosus ...
OBJECTIVE In this study, we examined the concentration of serum immunoglobulin free light chains (FLCs) in systemic lupus erythematosus (SLE) patients and investigated its association with various disease parameters in order to evaluate the role of FLCs as a potential biomarker in SLE. Furthermore, FLCs' association with Epstein-Barr virus (EBV) antibodies was examined. METHODS Using a nephel...
BACKGROUND The purpose of this exploratory study was threefold, ie, to clarify the unique psychosocial challenges facing those living with systemic lupus erythematosus (SLE), to distinguish which sociodemographic variables impact the lives of SLE patients, and generate knowledge regarding the way patients perceive SLE medication regimens. METHODS This was a cross-sectional exploratory study i...
BACKGROUND It is well known that interferon (IFN)-alpha is important to the pathogenesis of systemic lupus erythematosus (SLE). However, several reports have indicated that the number of IFN-alpha producing cells are decreased or that their function is defective in patients with SLE. We studied the function of plasmacytoid dendritic cells (pDCs) under persistent stimulation of Toll-like recepto...
OBJECTIVE Systemic lupus erythematosus (SLE) is a severe autoimmune disease with rare remission and recurrent flare. Epstein-Barr virus (EBV) infection has been reported to be strongly associated with SLE in the United States, but with an inconclusive role in Asia. We investigated the role of EBV infection in patients with SLE in Taiwan, with one of the highest population densities in Asia. M...
OBJECTIVE To evaluate the specificity of expression patterns of cell-free circulating microRNAs (miRNAs) in systemic lupus erythematosus (SLE). METHODS Total RNA was purified from plasma, and 45 different specific, mature miRNAs were determined using quantitative reverse transcription-polymerase chain reaction assays. A total of 409 plasma samples were obtained from 364 different patients wit...
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