899 Sleep Deprivation Effects on Monetary Rewards—Libedinsky et al INTRODUCTION An increasing number of persons do not get adequate sleep.1 Experimentally induced sleep deprivation has been shown to affect decision-making, including risky behavior, in simulated real-world scenarios2,3 and laboratory settings.4-8 Increased risk taking in these studies could have arisen from altered valuation of ...

OBJECTIVE To investigate the effect of sleep deprivation on corticospinal excitability in patients affected by juvenile myoclonic epilepsy (JME) using different transcranial magnetic stimulation (TMS) parameters. METHODS Ten patients with JME and 10 normal subjects underwent partial sleep deprivation. Motor threshold (MT), motor evoked potential amplitude (MEP), and silent period (SP) were re...

OBJECTIVE Resident work hour restrictions have been mandated in the USA largely out of concern that sleep deprivation compromises doctor performance and patient care. However, individuals' ability to recognise the effects of sleep deprivation has not been studied in medical education. We examined the perceived impact of sleep deprivation among different groups of postgraduate medical trainees. ...

In mammals and birds, sleep is associated with specific cortical electroencephalogram (EEG) patterns (Box 1), which may be divided into rapid eye movement (REM) and non-rapid eye movement (NREM) sleep [1]. The only known exceptions include the primitive egg-laying mammals echidnae [2], where a REM/NREM mixed state has been proposed. Some birds and marine mammals also have brief REM sleep and un...

To determine if 12-h sleep deprivation disrupts neural plasticity, we compared long-term potentiation (LTP) in five sleep-deprived and five control rats. Thirty minutes after tetanus population spike amplitude increased 101 +/- 15% in 16 slices from sleep deprived rats and 139 +/- 14% in 14 slices from control rats. This significant (P < 0.05) reduction of LTP, the first demonstration that the ...

Hippocampal cellular and molecular processes critical for memory consolidation are affected by the amount and quality of sleep attained. Questions remain with regard to how sleep enhances memory, what parameters of sleep after learning are optimal for memory consolidation, and what underlying hippocampal molecular players are dysregulated by sleep deprivation to impair memory consolidation and ...

INTRODUCTION Sleep deprivation has detrimental effects on cognitive processes, including decision making. The present study investigated how 72 h of sleep deprivation influenced individual neural performance in the Iowa gambling task using event-related potential technology. METHODS Eleven healthy male adults who participated in our study were randomized to be either in group with 72 h of soc...

Sleep deprivation causes a wide range of cognitive deficits like impairments in vigilance, memory and physiological processes. To our knowledge, few chronic sleep deprivation studies have related the possible electrodermal activity (EDA) changes that show sympathetic activation. In this study, we aimed to investigate the effects of a 21-days sleep deprivation on EDA and neurobehavioral changes ...

STUDY OBJECTIVES Partial sleep deprivation and alcohol consumption are a common combination, particularly among young drivers. We hypothesized that while low blood alcohol concentration (<0.05 g/dL) may not significantly increase crash risk, the combination of partial sleep deprivation and low blood alcohol concentration would cause significant performance impairment. DESIGN Experimental SE...

Sleep deprivation did not affect dopamine transporters (target for most wake-promoting medications) and thus dopamine increases are likely to reflect increases in dopamine cell firing and/or release rather than decreases in dopamine reuptake. Because dopamine-enhancing drugs increase wakefulness, we postulate that dopamine increases after sleep deprivation is a mechanism by which the brain main...