Slits are secreted proteins that bind to Roundabout (Robo) receptors. Slit-Robo signaling is best known for mediating axon repulsion in the developing nervous system. However, in recent years the functional repertoire of Slits and Robo has expanded tremendously and Slit-Robo signaling has been linked to roles in neurogenesis, angiogenesis and cancer progression among other processes. Likewise, ...

Spatiotemporal mapping of neural interactions through electrocorticography (ECoG) is the key to understanding brain functions and disorders. For the entire brain cortical areas, this approach has been challenging, especially in freely moving states, owing to the need for extensive craniotomy. Here, we introduce a flexible microelectrode array system, termed iWEBS, which can be inserted through ...

-A rotating side-scan sonar system was designed to make time-lapse sonographs of a circular area of the sea floor. To construct the system, the transducers of a commercial side-scan system (frequency 105 kHz; pulse length 0.1 ms; horizontal beam width 1°; vertical beam width 20°; beam depressed 10 ° with respect to horizontal) were mounted 2 m above the sea floor on a vertical shaft that had a ...

Making a position measurement to determine through which slit a particle has passed necessarily destroys the twin-slit interference pattern (see Fig. 1). This is the canonical example of Bohr’s complementarity principle [1, 2]. To defend this principle against Einstein’s recoiling slit gedankenexperiment, Bohr relied upon the recently (in 1927) derived Heisenberg uncertainty relation [3] to sho...

In order to meet the needs of performance-based seismic design, a new type of adaptive-slit shear wall that is easy to construct and behaves well under cyclic loading is introduced to improve the seismic performance of conventional shear wall structures. The seismic damage of an adaptive-slit shear wall develops gradually and it transforms from integral wall into slit wall. The mechanical chara...

The molecular mechanisms that generate dendrites in the CNS are poorly understood. The diffusible signal molecule Slit and the neuronally expressed receptor Robo mediate growth cone collapse in vivo. However, in cultured neurons, these molecules promote dendritic development. Here we examine the aCC motoneuron, one of the first CNS neurons to generate dendrites in Drosophila. Slit displays a dy...

We derive an analytic expression for the instrument profile of a slit spectrograph, also known as the line spread function. While this problem is not new, our treatment relies on the operatorial approach to the description of diffractive optical systems, which provides a general framework for the analysis of the performance of slit spectrographs under different illumination conditions. Based on...

Fabry-Perot-like resonant transmission of microwave radiation through a single subwavelength slit in a thick aluminum plate is quantified for a range of slit widths. Surprisingly, and in contrast to previous studies [e.g., Phys. Rev. Lett. 86, 5601 (2001)]], the resonant frequency exhibits a maximum as a function of slit width, decreasing as the slit width is reduced to less than 2% of the inci...

BACKGROUND Evidence regarding sublingual immunotherapy (SLIT) efficacy and its good safety profile has been demonstrated with pollen and house dust mite (HDM) allergens in the treatment of airway allergies. In addition, the use of grass pollen presents a SLIT disease-modifying treatment for respiratory allergies. OBJECTIVES The aim of this study was to demonstrate the efficacy of HDM-based SL...

The Drosophila heart tube represents a structure that similarly to vertebrates' primary heart tube exhibits a large lumen; the mechanisms promoting heart tube morphology in both Drosophila and vertebrates are poorly understood. We identified Multiplexin (Mp), the Drosophila orthologue of mammalian Collagen-XV/XVIII, and the only structural heart-specific protein described so far in Drosophila, ...