BACKGROUND Studies have shown that gene and environmental factors, such as BRCA1/2 mutations, ionized radiation, and chemical carcinogens, are related with breast cancer. X-ray repair cross-complementing group 3 (XRCC3) is involved in homologous repair of double DNA breaks. It was reported that Thr241Met single-nucleotide polymorphism (SNP) in XRCC3 is associated with increased risk of breast c...

Background Urine is a supersaturated solution with solutes in very high concentration. Matrix gla protein (MGP) is one of the proteins involved in inhibition of extracellular calcification. Among the various polymorphisms studied, polymorphism of SNP rs4236 in the MGP gene is found to have association with nephrolithiasis. We evaluated the significance of SNP rs4236 polymorphism in nephrolithia...

Abstract The hazel dormouse Muscardinus avellanarius presents an exemplary non-model species that is both locally threatened and whose genetic status not fully understood owing to insufficient resolution of the currently available molecular tools. We performed normalized Genotyping-by-Sequencing (nGBS) on 48 samples collected across European distribution, aiming at discovering useful single nuc...

There has been limited research on genome-wide association with physical activity (PA). This study ascertained genetic associations between PA and 344,893 single nucleotide polymorphism (SNP) markers in 8842 Korean samples. PA data were obtained from a validated questionnaire that included information on PA intensity and duration. Metabolic equivalent of tasks were calculated to estimate the to...

BACKGROUND Cell surface biomarker CD44 plays an important role in breast cancer cell growth, differentiation, invasion, angiogenesis and tumour metastasis. Therefore, we aimed to investigate the role of CD44 gene polymorphisms in breast cancer risk and prognosis in North Indian population. MATERIALS & METHODS A total of 258 breast cancer patients and 241 healthy controls were included in the ...

normal 0 false false false en-us x-none fa microsoftinternetexplorer4 aim : the purpose of this study was to determine the relationship of rs4444903 (egf+61a/g) snp genotype with colorectal cancer and tumor stage in an iranian population. background : epidermal growth factor ( egf ) is one of the important proteins that determine survival of cells. egf binds to its receptor on the cell surface ...

Reproduction in domestic animal is a very complex process. The process starts from gamete formation, release, transport, fertilization, embryo and fetal development until delivery of the offspring by dam. holds most important role determining success livestock farming, profit or loss. genetic selection reproductive traits became an program to find out merit candidate dam bulls. At early time, f...

This research aimed to assess the genetic polymorphism of BMP15 gene concerning sex hormone levels and birth type in Awassi ewes. The genome DNA 138 ewes was isolated (52 produced a singleton 86 twins). exon-2 amplifiable by polymerase chain reaction (PCR), so two genotypes were identified based on 141 bp amplicons: TT TA. A sequencing revealed novel mutation, c.50980646T>A, TA genotype. single...

To assess the association between polymorphisms of the IL-6 -174 G/C and Behçet's disease (BD) in Tunisian patients. DNA was extracted from blood samples taken from 43 Tunisian patients and 43 healthy controls. The polymorphisms were analyzed by PCR with the PCR-RFLP. No significant association was found between patients and controls concerning polymorphism of IL6 -174 G/C between the (allelic ...

AIM OF THE STUDY A recent breast cancer genome-wide association study (GWAS) identified single-nucleotide polymorphism (SNP) rs2046210 on 6q25.1 showing a strong association with breast cancer risk. Numerous association studies have been conducted to investigate the relationship between this polymorphism and breast cancer risk in various populations. There have been conflicting reports about th...