We describe here the synthesis of azide-functionalised iridium(III) bisterpyridines using the "chemistry on the complex" strategy. The resulting azide-complexes are then used in the copper(I)-catalysed azide-alkyne Huisgen 1,3-dipolar cycloaddition "click chemistry" reaction to from the corresponding triazole-functionalised iridium(III) bisterpyridines. The photophysical characteristics, includ...

In this protocol, 3-(2-carboxybenzoyl)-1-methyl-1H-imidazol-3-ium chloride [Cbmim]Cl and sulfonic acid functionalized pyridinium chloride [pyridine-SO3H]Cl as a new, reusable, and green Brønsted acidic ionic liquid (BAIL) catalyst were synthesized and successfully used for the one-pot ring opening of epoxide with sodium azide (NaN3) in water at room temperature. Epoxides under ring-opening easi...

Azide (0.2 to 5.0 mM) and chloretone (2.0 to 15.0 mM) reversibly inhibited 20 to 90 per cent of the resting respiration of frog sciatic nerves, and caused a loss of potassium and a gain of sodium in this tissue. The changes in ionic contents that developed after 5 or 10 hours were roughly correlated with the degree of respiratory depression, but the time courses of these changes were different ...

Stimulation of intact or desheathed frog sciatic nerves produced an increase in the sodium content and a decrease in the potassium content of this tissue. In desheathed preparations the magnitudes of the changes in ionic contents decreased as the concentration of the potassium in the bathing solution was increased, while changing the external sodium concentration produced small effects on the i...

Materials and methods The CA3 neurons were chemically lesioned by intracerebrally administration of NaN3 in doses of 8 and 16 mg/ml. To examine learning functions Morris maze was used. During acquisition trials animals had to find a black platform within 120 s. We measured the “escape latency"(msec). Detailed histopathology of brain was performed at the termination of the study. Learning functi...

The synthesis of nucleoside analogues incorporating 4-(5-pyrimidinyl)-1,2,3-triazole aglycons as expanded purine nucleobase mimics were accessed using the copper-catalyzed azide-alkyne Huisgen cycloaddition between a ribosyl azide and 5-alkynylpyrimidines. Depending on the nature of the alkyne employed, other nucleoside analogues that possess fluorescence or potential metal-binding properties w...

Complexes of the general formula [Ni2L2(l1,1-N3)2(N3)2] have been synthesised in good yields by reacting Ni(NO3)2 Æ 6H2O wit L in the presence of excess of sodium azide in methanol at room temperature. Here L is N,N-bis(2-pyridylmethyl)amine (L) an N-(2-pyridylmethyl)-N 0,N 0-diethylethylenediamine (L). The X-ray structures of both compounds reveal that the N,N,N coordina ing reduced Schiff bas...