Solid dispersion complexes of meloxicam were prepared by using cyclodextrins (BCD, HPBCD), PVP and urea by kneading method in different molar and weight ratios. The complexes were characterized by DSC and IR, suggested that no chemical interaction between drug and carrier. The solubility, dissolution and permeability was studied for prepared complexes. The solubility, dissolution and permeabili...

Theoretical calculations are presented of solid-liquid equilibrium for linear quadrupolar molecules, focusing especially on the ratio of the triple point temperature to the critical temperature. The proposed treatment uses the hard quadrupolar dumbbell model as the reference system, and incorporates the effect of dispersion forces through a mean-field term. The reference system of quadrt/polar ...

A lot of pharmaceutical substances have a poor solubility that limits their absorption and distribution to the targeted sites to elicit the desired action without causing untoward effects on healthy cells or tissues. For such drugs, new modes of delivery have to be developed for efficient and effective delivery of the drug to the target site. Formation of magnetically active solid dispersion of...

Solid Dispersions were prepared by solvent evaporation technique using microcrystalline cellulose, PEG 4000, PEG 6000, PVP-K30 and Gelucire 50/13. Further objective of the project was to develop fast release surface solid dispersion of glibenclamide and compressed at low pressure to form fast-melting pharmaceutical tablet. In this study, we used sodium starch glycolate for mouth dissolving natu...

Two column tests were performed in conditions emulating vertical flow beneath the leachate table in a biologically active landfill to determine dominant transport mechanisms occurring in landfills. An improved understanding of contaminant transport process in wastes is required for developing better predictions about potential length of the long term aftercare of landfills, currently measured i...

Gliclazide is a second-generation hypoglycaemic sulfonylurea that is useful in the treatment of Type 2 diabetes mellitus. It shows low aqueous solubility and dissolution rate and often shows low and irregular bioavailability after oral administration. This paper describes an approach to improve the Solubility of gliclazide by using solid dispersions (SDs) in polyethylene glycol 4000 (PEG 4000)....

in this paper, we investigated the corrected plasmon dispersion relation for graphene in presence of a constant magnetic field which it includes a quantum term arising from the collective electron density wave interference effects. by using quantum hydrodynamic plasma model which incorporates the important quantum statistical pressure and electron diffraction force, the longitudinal plasmons ar...

New solid strong bases were fabricated at room temperature by grafting lithium-containing molecular precursors onto β-cyclodextrin. The solid bases show strong basicity with a molecular-level dispersion of lithium sites, which are highly active in transesterification reactions and impossible to realize through the traditional high-temperature method.

This white paper presents a number of mixing technologies and techniques employed in solid dispersion and dissolution. The aim of this paper is to provide practical information on the efficient use of specialty mixing equipment for the preparation of low, medium and high viscosity solid-liquid mixtures under low and high shear conditions.

PURPOSE Solid dispersions have been efficient in improving the dissolution rate and bioavailability of hydrophobic drugs. The aim of the present study was enhancement of the dissolution profile of Spironolactone using solid dispersion. METHODS Spironolactone solid dispersions (1:1, 1:2 and 2:1 drug: carrier weight ratio) were prepared by polyethylene glycol (PEG) 6000 as a carrier by hot melt...