نتایج جستجو برای: soluble vegfr1
تعداد نتایج: 89808 فیلتر نتایج به سال:
UNLABELLED A proangiogenic role for Jagged (JAG)-dependent activation of NOTCH signaling in the endothelium has yet to be described. Using proteins that encoded different NOTCH1 EGF-like repeats, we identified unique regions of Delta-like ligand (DLL)-class and JAG-class ligand-receptor interactions, and developed NOTCH decoys that function as ligand-specific NOTCH inhibitors. N110-24 decoy blo...
Tumor cell migration, invasion, and angiogenesis are important determinants of tumor aggressiveness, and these traits have been associated with the motility stimulating protein autotaxin (ATX). This protein is a member of the ectonucleotide pyrophosphatase and phosphodiesterase family of enzymes, but unlike other members of this group, ATX possesses lysophospholipase D activity. This enzymatic ...
Vascular endothelial growth factor (VEGF) plays an essential role in angiogenesis. This includes developmental angiogenesis as the loss of a single allele is embryonic lethal due to lack of development of endothelial cells. During early development, endothelial cells depend on VEGF for survival and if it is withdrawn, massive apoptosis results. This is not true in adult organisms; withdrawal of...
Methods:We have tested, in vitro and in vivo, the effects of regorafenib, a novel oral multikinase inhibitor that targets protein kinases involved in tumor angiogenesis [VEGFR1–3 and tyrosine kinase with immunoglobulin and epidermal growth factor homology domain 2 (TIE2)], oncogenesis (KIT, RET and RAF) and the tumor microenvironment [plateletderived growth factor receptor-b and fibroblast grow...
اندومتریوز یکی از بیماری های زنان است که به وسیله رشد بافت شبه اندومتر رحم در جایی خارج از حفره رحمی تعریف می شود. فاکتور رشد اندوتلیال عروق (vegf) یکی از مهمترین فاکتورهای مرتبط با اندومتریوز است که بوسیله اینترکشن با رسپتورهایش،flt-1 و flk-1/kdr، عمل می کند. هدف این مطالعه بررسی بیان vegf و رسپتورهای آن و ارتباط آن ها با تکوین و بقای ضایعات اندومتریوزی در سراسر چرخه قاعدگی است. نمونه ها در فا...
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