Cyclin dependent kinases (cdks) regulate cell cycle progression and transcription. We report here that the transcriptional co-activator PCAF directly interacts with cdk2. This interaction is mainly produced during S and G(2)/M phases of the cell cycle. As a consequence of this association, PCAF inhibits the activity of cyclin/cdk2 complexes. This effect is specific for cdk2 because PCAF does no...

Forward Congratulations! You've (somehow) managed to stumble across my vast repository of knowledge on all sorts of fun and exciting topics somehow related to the work of this robotics PhD student. This document contains all of my notes since I started my PhD in 2012. Many portions have come from my study of various internet sources including others' personal notes; I found these to be extremel...

Abstract This paper addresses the issue of a non-assigned case in Czech. so-called default can be found many languages and its behavior seems to largely determined by type given language. English, being poor language, does not have options for default; it is basically nominative or accusative that are somehow available. Czech, on other hand, rich offers greater variety. The considers special en...

In hyperspectral imaging the replacement model where a target, if present, partly replaces disturbance is often advocated. this paper, we consider somehow more realistic only low-rank background substituted for target while residual noise, which belongs to orthogonal complement, unaffected by presence/absence of target. A two-step generalized likelkihood ratio test formulated such model. Furthe...

At Philebus 53c4–55a12, Plato's Socrates identifies pleasure as an ontologically inferior "becoming" (γένεσις) rather than a "being" (οὐσία) and then uses this information to infer that pleasure, somehow, lacks value. This paper argues γένεσις argument is not about the goodness of individual, particular episodes but instead targets identification good around which we ought organize our lives. I...

Abstract Is everything about reality either qualitative or somehow determined by the character of itself? Metaphysical anti-Haecceitism is often taken to be claim that this case, and entail fundamentally qualitative. In paper, I (1) argue against idea metaphysical should characterized in such terms, (2) defend a novel way phrase view. This will done taking main arguments for as guide singling o...

Climate change poses a serious threat to the development of current and future generations. Therefore, Carbon Dioxide Capture, Transportation, Utilization Storage (CCUS) has emerged as an essential tool mitigate such impacts global warming along with other initiatives strategic decisions energy transition conservation, sustainable practices amongst others. This article is focused on CCUS more s...

Within a theoretical framework grounded in design for learning, this article presents research project about pupils’ engagement during programming education. In design-theoretical perspective, everyone who is somehow engaged learning process designer. The results show that how pupils their when related to different types of engagement. By analysing programming, the study contribute an insight b...

leadership is important for nurturing employee creativity. although how leaders can influence employee creativity is somehow unclear, previous studies show that leadership can enhance employees’ willingness to share knowledge. this study examines how leader-member exchange (lmx) affects employees’ creative work involvement through knowledge sharing. data (n=385) was collected utilizing a questi...