HAMLET (Human a-lactalbumin made lethal to tumor cells) is a protein-lipid complex that kills tumor cells and immature cells but spares healthy, differentiated cells. The complex is formed from partially unfolded a-lactalbumin and oleic acid, both of which are abundant constituents of human milk. The folding change occurs after removal of Ca2+ from native a-lactalbumin, and the partially unfold...

Studies on H.M. generated five main findings: that memory is a distinct psychological function, that amnesia spares short-term and working memory, that amnesia is an impairment of declarative and episodic memory, that the hippocampus is a core brain structure supporting memory, and that the hippocampus supports the permanent consolidation of memories. Each of these basic findings has recently b...

UNLABELLED Radiotherapy (RT) is effective in head and neck cancers. Following RT, dryness and dysphagia are the 2 major sequelae which alter the quality of life (QOL) significantly in these patients. There is randomized evidence that Intensity Modulated Radiotherapy (IMRT) effectively spares the parotid glands. IMRT has been attempted in all head and neck subsites with encouraging results (disc...

Coxsackie viruses are enteroviruses most common in children. Coxsackie B viral infections often present with biphasic fever, headache, pharyngitis, nausea/vomiting, diarrhea and a maculopapular rash that spares the palms and soles. These clinical features may be present in other viral infections. We present a case of a hospitalized adult with rash and fever with highly elevated ferritin levels ...

of partial or complete necrosis of the renal cortex, and this usually spares a thin tissue rim under the capsule and a thicker layer adjacent to the corticomedullary junction. It typically evolves bilaterally, although a few unilateral RCN cases have been reported in patients with unilateral hydronephrosis or arterial stenosis. We encountered a case of bilateral RCN, including limited RCN in a ...

Seeking compounds preferentially potent and selective for MMP-13, we reported in the preceding Letter on a series of hydroxamic acids with a flexible benzamide tail groups.(1a) Here, we replace the amide moiety with non-hydrolyzable heterocycles in an effort to improve half-life. We identify a hydroxamate tetrazole 4e that spares MMP-1 and -14, shows >400-fold selectivity versus MMP-8 and >600-...

The excellent reliability provided by RAID Level 5 data organization has been seen to be insuucient for future mass storage systems. We analyze the multi-dimensional disk array in search of the necessary improved reliability. The paper begins by introducing multi-dimensional disk array data organization schemes based on maximum distance separable error correcting codes and incorporating both st...

This paper describes a cost model developed to assess the cost ramifications of the transition from tinlead to lead-free electronic parts. All tin-lead, all lead-free and mixed assembly approaches are considered. The model makes basic assumptions of a fixed generic set of applications, incorporates a cost of plan development, and includes the costs of reprocessing tin lead to lead free and vice...

We have identified a novel chicken gene, cMespo, which encodes a basic-helix-loop-helix (bHLH) protein with sequence homology to a subgroup of bHLH transcription factors that have been implicated in somitogenesis. cMespo transcripts are first found in the primitive streak of gastrulating chick embryos (HH stage 4) and continue to accumulate in presomitic mesoderm (PSM) until somite formation ha...