Behavioral and EEG studies suggest spatial attention is allocated as a gradient in which processing benefits decrease away from an attended location. Yet the spatiotemporal dynamics of cortical processes that contribute to attentional gradients are unclear. We measured EEG while participants (n = 35) performed an auditory spatial attention task that required a button press to sounds at one targ...

One of the most common causes of IC failure is interconnect electromigration (EM), which exhibits a rate that is exponentially dependent on temperature. As a result, EM rate is one of the major determinants of the maximum tolerable operating temperature for an IC and of resulting cooling costs. Previous EM models have assumed a uniform, typically worst-case, temperature. This paper presents a m...

Spatial receptive fields of primary auditory (AI) neurons were studied by delivering, binaurally, synthesized virtual-space signals via earphones to cats under barbiturate anesthesia. Signals were broadband or narrowband transients presented in quiet anechoic space or in acoustic space filled with uncorrelated continuous broadband noise. In the absence of background noise, AI virtual space rece...

Spatial separation of component enzymes in a pathway creates microdomains and gradients of signaling activities. Imaging techniques and computational modeling help us to understand the complex relationships between signaling and spatial information. In this issue, Neves et al. (2008) report how the propagation of spatial information is controlled by the shape of hippocampal neurons and feedback...

Metabolic alterations including increased glycolysis are a common feature of many cancers. In their recent study, Lowengrub, Waterman, and colleagues (Lee et al, 2017) report a spatial pattern of glycolysis in solid tumors that occurs within the tumor microenvironment. This spatial organization is linked to gradients derived from Wnt signaling and nutrient availability that mediate a reaction-d...