The deprotonative functionalization of α,α-difluoromethyl ketones is described herein. Using a catalytic organosuperbase and silane additive, the corresponding difluoroenolate could be generated trapped with aldehydes to deliver various α,α-difluoro-β-hydroxy in high yields. This new strategy tolerates numerous functional groups represents access by direct deprotonation difluoromethyl unit. dia...

Using the predictive algorithm of Rothbard and Taylor (1988. EMBO J. 7:93) and the primary structure of gp63 (Button, L., and M.R. McMaster. 1988. J. Exp. Med. 167:724; Miller, R.A., S.G. Reed, and M. Parsons. 1990. Mol. Biochem. Parasitol. 39:267) we have been able to delineate the structures of a number of gp63 T-cell epitopes which stimulate the proliferation of CD4+ cells. One of these synt...

Deep learning applications are able to recognise images and speech with great accuracy, and their use is now everywhere in our daily lives. However, developing deep learning architectures such as deep neural networks in embedded systems is a challenging task because of the demanding computational resources and power consumption. Hence, sophisticated algorithms and methods that exploit the hardw...

If 91 and 23 are algebras, where 9Is23, and 6 is a congruence relation on 91, let 0® be the smallest congruence relation on 93 containing 0. 91 is called a congruence subalgebra of 93 if 9ls93 and, for every congruence relation 0 on 91, 0*n|9I|2=0. Elementary subalgebras are congruence subalgebras, and there are Directed Union and Loewenheim-Skolem Theorems for congruence subalgebras analogous ...

Computations on clusters and computational GRIDS encounter similar situations where the processors used have different speeds and local RAM. In order to have efficient computations with processors of different speeds and local RAM, load balancing is necessary. That is, faster processors are given more work or larger domains to compute than the slower processors so that all processors finish the...

Normal rabbit alveolar macrophages were infected in vitro with Candida albicans. Early after infection, germ tube formation of phagocytized C. albicans was inhibited in contrast to extracellular (nonphagocytized) C. albicans. Over and 8-h period, plate counts of C. albicans incubated with alveolar macrophages revealed a decrease in colony-forming units in contrast to C. albicans alone. In addit...

Using the predictive algorithm of Rothbard and Taylor (1988 . EMBOJ. 7:93) and the primary structure of gp63 (Button, L., and M.R . McMaster. 1988 . J. Exp. Med. 167:724 ; Miller, R.A., S.G . Reed, and M. Parsons . 1990 . Mol. Biochem. Parasitol. 39:267) we have been able to delineate the structures of a number of gp63 T-cell epitopes which stimulate the proliferation of CD4' cells . One of the...