نتایج جستجو برای: spectrum antibiotics
تعداد نتایج: 288353 فیلتر نتایج به سال:
Postoperative infections are a major concern in patients that receive implants. These infections generally occur in areas with poor blood flow and pathogens do not always respond to antibiotic treatment. With the latest developments in nanotechnology, the incorporation of antibiotics into prosthetic implants may soon become a standard procedure. The success will, however, depend on the ability ...
Nonribosomal peptide antibiotics, including polymyxin, vancomycin, and teixobactin, most of which contain D-amino acids, are highly effective against multidrug-resistant bacteria. However, overusing antibiotics while ignoring the risk of resistance arising has inexorably led to widespread emergence of resistant bacteria. Therefore, elucidation of the emerging mechanisms of resistance to nonribo...
Most pharmaceutical companies have stopped or have severely limited investments to discover and develop new antibiotics to treat the increasing prevalence of infections caused by multi-drug resistant bacteria, because the return on investment has been mostly negative for antibiotics that received marketing approved in the last few decades. In contrast, a few small companies have taken on this c...
INTRODUCTION................................................................. 13 PRECLINICAL TESTING STAGES ................................................................. 13 Discovery of New Antibiotics ................................................................. 13 Establishment of SAR ................................................................. 15 Animal Models for Studying the P...
Antibiotics resistance poses catastrophic threat to global public health. Novel insights into the underlying mechanisms of action will inspire better measures to control drug resistance. Fluoroquinolones are potent and widely prescribed broad-spectrum antibiotics. Bacterial protein degradation pathways represent novel druggable target for the development of new classes of antibiotics. Mycobacte...
Background The clinical management of bacterial infection computes factors related to bacteria (e.g., resistance profile [1]), antibiotics (e.g., activity spectrum, distribution volume, etc.), host characteristics (e.g., vascularization of the infected tissue, effectiveness of host defenses, etc.), as well as pharmacokinetic (PK) parameters [2]. The serum inhibitory (SIT) and bactericidal titer...
Treatment and Follow-up: Broad-spectrum antibiotics given at outset were extended with additional antibiotics. Treatment consisted of fi ve separate surgeries involving extensive debridement of necrotic tissue amounting to approximately 55 to 65 percent of the patient’s body surface area. The patient was eventually released to a burn center for skin grafting and wound closure and in less than t...
Background In the era of broad spectrum antibiotics it is sometimes difficult to choose the best antimicrobial regimens. Because of misuse and abuse of antimicrobial usage, the level of resistance is increasing and sometimes we do not have treatment options. Infectious diseases specialists traditionally have the leadership role in optimal use of antimicrobials. Antimicrobial stewardship represe...
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