OBJECTIVES Bisphenol A diglycidyl ether (BADGE) is a liquid compound obtained by condensation of two molecules of epichlorohydrin with one molecule of bisphenol A. General and reproductive toxicity with BADGE has been reported higher than 1000 mg/kg/day. This study was performed to show the effects of acute exposure to BADGE below 1000 mg/kg/day on the testis in adult male rats. METHODS BADGE...

objective: in this study we investigated the effects of spearmint (mentha spicata labiatae) on the reproductive system, fertility and number of offspring in adult male rats. materials and methods: adult wistar male rats in one control (c) and three experimental groups (i, ii and iii) received 0, 10, 20 and 40 mg/kg spearmint extract orally for 45 days, respectively.  following this treatment, t...

Background: Ceftriaxone is a third-generation Cephaloporin antibiotic. It has broad spectrum activity against gram-positive and gram-negative bacteria. There are some reports about its adverse effects on sperm quality and quantity but there is a need for more investigations so we did it. Materials and Methods: 40 adult male mice were divided into 3 groups as followings: a control group, high do...

Procarbazine causes dose-dependent decreases in sperm count after a single i.p. injection in (C57BL/6 X DBA/2)F1 male mice. Two antioxidants, N-acetylcysteine and sodium ascorbate, administered with equimolar doses of procarbazine decreased the spermatotoxicity of procarbazine. At the highest doses of procarbazine (400 mg/kg) that caused a 56% decrease in sperm count, equimolar doses of N-acety...

OBJECTIVE To compare semen parameters, pregnancy, recurrence, and complication rates after microsurgical and nonmagnified subinguinal varicocelectomy for infertile men. DESIGN Prospective, randomized study. SETTING Ghodran General Hospital, Kingdom of Saudi Arabia. PATIENT(S) One hundred sixty-two infertile male patients with varicocele. INTERVENTION(S) Eighty-two patients were treated ...

BACKGROUND Reverse pharmacology for drug development has been highly productive and cost-effective in recent past as it is based on the documented therapeutic effects of plants in ancient texts. Afrodet Plus(®) is formulated for the treatment of male infertility, which contains ancient herbo-minerals. Its efficacy and safety are validated through this animal study in reverse pharmacology mode. ...

INTRODUCTION There is little data concerning the ability of Eurycoma longifolia Jack (EL) to reverse the inhibitory effects of estrogen on testosterone production and spermatogenesis. The aim of the present study was to determine the effect of EL on testicular histology and sperm count in estrogen-treated male rats. METHODS Adult male Sprague-Dawley rats weighing 200-250 g were divided into f...