In spinal cord injuries, direct trauma by edges of sublaxated or dislocated vertebrae and indirect ischemia as a result of vascular injury necrotize the neural tissue. After spinal cord injury, tissue loss appears as micro- or macrocavitation. Accumulations of non-neuronal cells substitute spared tissue and halts axon regrowth. Lack of supporting cells (secreting trophic factors and matrix) agg...

Ischemia-induced lipid peroxidation is one of the most important factors produdng tissue damage in spinal cord injury. In this study a standard spinal cord injury model in rats was used and the effects of chronic administration of Selenium (3ppm/lt water orally) before and alpha-tocopherol management (100 mg/kg. intraperitoneally) just after the trauma were investigated. For this purpose animal...

In spinal cord injuries, direct trauma by edges of sublaxated or dislocated vertebrae and indirect ischemia as a result of vascular injury necrotize the neural tissue. After spinal cord injury, tissue loss appears as micro- or macrocavitation. Accumulations of non-neuronal cells substitute spared tissue and halts axon regrowth. Lack of supporting cells (secreting trophic factors and matrix) agg...

Secondary injury in the spinal cord, which results in axonal degeneration, scar and cavity formation and cell death, occurs around the site of the initial trauma and is a primary cause for the lack of axonal regeneration observed after spinal cord injury (SCI). The immune response after SCI is under investigation as a potential mediator of secondary injury. Treatment of SCI with 810 nm light su...

The presence of air within the spinal canal secondary to trauma is a rare condition. These rare cases are generally asymptomatic. We report our first case of closed thoracic trauma with pneumorachis associated with neurological disorders. According to a review of the literature and after personal record analysis, neurologic symptoms can be correlated to the occurrence of intraspinal air. Theref...

OBJECTIVE To evaluate the effect of monosialoganglioside (GM-1) in spinal cord trauma patients seen in our service who have not been treated with methylprednisolone. METHODS Thirty patients with acute spinal cord trauma were randomly divided into two groups. In Group 1, patients received 200 mg GM-1 in the initial assessment and thereafter received 100 mg intravenous per day for 30 days and G...

AIM Spinal Cord Injury (SCI) is a devastating health problem both for the patient and the clinician. Numerous treatment modalities have been studied to reverse the effects of spinal cord injury. Herein is reported the effects and the comparison of Alpha Lipoic Acid and N-Acetyl Cysteine on rats with SCI. MATERIAL AND METHODS 38 adult male Sprague-Dawley rats were randomly divided into 5 group...

Tissue loss after spinal trauma is biphasic, with initial mechanical/haemorrhagic damage at the time of impact being followed by gradual secondary expansion into adjacent, previously unaffected tissue. Limiting the extent of this secondary expansion of tissue damage has the potential to preserve greater residual spinal cord function in patients. The acute tissue hypoxia resulting from spinal co...

Tissue loss after spinal trauma is biphasic, with initial mechanical/haemorrhagic damage at the time of impact being followed by gradual secondary expansion into adjacent, previously unaffected tissue. Limiting the extent of this secondary expansion of tissue damage has the potential to preserve greater residual spinal cord function in patients. The acute tissue hypoxia resulting from spinal co...

The aim of the study was to analyse the risk of symptomatic myelopathy after minor trauma in patients with asymptomatic spondylotic cervical spinal cord encroachment (ASCCE). In a cohort of 199 patients with ASCCE, previously followed prospectively in a study investigating progression into symptomatic myelopathy, the authors looked retrospectively for traumatic episodes that may have involved i...