The effects of Bay K 8644 on the high-threshold calcium channel was investigated by means of the whole-cell patch-clamp technique in single guinea pig ventricular myocytes. The goal of the experiments was to characterize the inhibitory effects of Bay K 8644 on the calcium channel, and identify the factors that influence the inhibition. Bay K 8644 was found to have strong calcium channel antagon...

Introduction: Recent studies have shown the presence of Cl- channels in heart and liver mitochondrial membranes. In this work, we have characterized the functional profile of a Cl- channel from rat brain mitochondria. Methods: After removing and homogenizing the rat brain, the supernatant was separately centrifuged in MSEdigitonin, H2O and Na2CO3 and mitochondrial inner membrane vesicles wer...

Introduction: Different ATP-sensitive potassium channels have been detected in the mitochondrial inner membrane of cells. They are suggested to be involved in cell processes including cell protection. Here, we characterized the biophysical and electropharmacological properties of a KATP channel in the brain mitochondrial inner membranes. Methods: After removing and homogenizing the rat brain...

The rating curve is the relationship between the water stage and the associated discharge in a givensection of a channel. In steady flow, this relationship usually has exponential type, whereas inunsteady it flow has a looped shape. Since direct developing of actual looped rating curve by usinghydrometric methods is merely possible, steady-state rating curve is commonly used as a downstreamboun...

The capability of sand constitutive models is remarkably improved by taking into account the effect of soil state in their formulations. In this study, it has been shown that considering the effect of soil state leads to better simulation of soil instability of shear banding type. To this aim, constitutive equations of a state dependent sand model are explained first. Consequently, the general ...