1 Proposed Study Stereology, a form of sampling theory, is a group of statistical methods used for estimating properties such as volume and surface area of a three-dimensional object using information only available on a two-dimensional plane section through the object 2, 9]. It has applications in many areas of science, in particular anatomy, geology and materials science 2]. Conceptually, ste...

The afferent synapse between the auditory nerve fiber and the inner hair cell (IHC) represents a critical junction for hearing. Elucidation of the structure at this site will help establish the substrate for normal sound encoding as well as pathologic processes associated with hearing dysfunction. Previous applications of unbiased (design-based) stereological principles have expanded our knowle...

Design and Measurements: Volumes are reconstructed by defining transformations that align the entire area of adjacent sections. Whole-field alignment requires rotation, translation, skew, scaling, and second-order nonlinear deformations. Such transformations are implemented by a linear combination of bivariate polynomials. Computer software for generating transformations based on user input is ...

Summary It was a major breakthrough when design‐based stereological methods for vertical sections were developed by Adrian Baddeley and coworkers in the 1980s. Most importantly, it shown how to estimate fashion surface area from observations random with uniform position rotation around axis. The great practical importance of these developments is due fact that some biostructures can only be rec...