OBJECTIVE To examine the association between use of aspirin or other non-steroidal anti-inflammatory drugs and intracerebral haemorrhage. DESIGN Case-control study. SETTING 13 major city hospitals in the Melbourne and metropolitan area. SUBJECTS 331 consecutive cases of stroke verified by computed tomography or postmortem examination, and 331 age (+/- 5 years) and sex matched controls who...

background & aim:  non-steroidal anti-inflammatory drugs (nsaids) are commonly used in clinical medicine. the adverse effects they produce in the gastrointestinal tract however, often limit their utility. oxidative stress has been shown to occur in the small intestine in response to the oral administration of indomethacin. in view of this, the effect of thyme essential oil, an agent with an...

A simple and practical method for synthesis of the D-ring modified steroidal dienamides (4a-k) from the steroidal α,α-dicyanoalkene 3 and aldehydes via vinylogous aldol reaction was first reported. By using NaOAc as a base, the desired products were obtained in moderate to good yields in ethanol under mild conditions. All the synthesized steroidal dienamides are new and are currently being eval...