Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe adverse cutaneous reactions to drugs. We describe the case of a 19 year old patient with SJS/TEN overlap syndrome, who developed severe interstitial pneumonia after she had received antiepileptic drugs. A cytomegalovirus infection was diagnosed by Real Time Polymerase Chain Reaction (RT-PCR) detection on Bronchoalveo...

Lamotrigine is an antiepileptic drug used for the treatment of epilepsy, bipolar disorder and numerous off-label uses. The development of rash significantly affects its use. The most concerning of these adverse reactions is Stevens-Johnson syndrome/toxic epidermal necrolysis. We performed a systematic review of randomized controlled trials using lamotrigine as a monotherapy to quantify the inci...

Abstract Introduction Osteo-odonto-keratoprosthesis (OOKP), “tooth-in-eye surgery”, is a rare, complex surgery offered to certain patients with bilateral corneal blindness. Indications for the include and range from: Steven-Johnson syndrome end-stage ocular surface diseases. OOKP consists of two stages undertaken four months apart. Surgical complications can be divided into intraoperative follo...

Aims—To understand the immunopathogenesis of the corneal conjunctivalisation in Stevens–Johnson syndrome. Methods—Conjunctivalised corneas from five patients with Stevens–Johnson syndrome were studied immunohistochemically for several cell surface antigens and two cytokines. Chemical injury specimens were also studied. Results—In all cases, immunohistochemistry revealed LFA-1, CD4, CD8, and CD6...

Stevens-Johnson syndrome is an uncommon life threatening disease generally induced by drugs. Antibiotics, mainly sulphonamides, are the most involved drugs in Stevens-Johnson syndrome in children. Co-amoxiclav is a well tolerated antibiotic. It has never been reported to cause, lonely this syndrome in children. Herein, we report a co-amoxiclav-induced Stevens-Johnson syndrome occurring in an 18...

OBJECTIVES The aims of this review are to summarize the definitions, causes, and clinical course as well as the current understanding of the genetic background, mechanism of disease, and therapy of toxic epidermal necrolysis and Stevens-Johnson syndrome. DATA SOURCES PubMed was searched using the terms toxic epidermal necrolysis, Stevens-Johnson syndrome, drug toxicity, drug interaction, and ...

We report a case of Dubin-Johnson syndrome presenting with neonatal cholestasis. Liver histology was studied during the neonatal period and at 6 years of age. Distinct brownish pigment granules in hepatocytes were noted. This case confirms that Dubin-Johnson syndrome is a cause of neonatal cholestasis.

Euan A. Ashley, MRCP, DPhil, Chair; Ray E. Hershberger, MD, Co-Chair; Colleen Caleshu, ScM, CGC; Patrick T. Ellinor, MD, PhD, FAHA; Joe G.N. Garcia, MD; David M. Herrington, MD, FAHA; Carolyn Y. Ho, MD; Julie A. Johnson, PharmD; Steven J. Kittner, MD, FAHA; Calum A. MacRae, MD, PhD; Gia Mudd-Martin, RN, MPH, PhD; Daniel J. Rader, MD, FAHA; Dan M. Roden, MD, FAHA; Derek Scholes, PhD; Frank W. Se...

Steven Silverstein*, Brian P. Keane, Randolph Blake, Anne Giersch, Michael Green and Szabolcs Kéri 1 Department of Psychiatry, Robert Wood Johnson Medical School, and University Behavioral Health Care, Rutgers, The State University of New Jersey, Piscataway, NJ, USA 2 Department of Psychology, Vanderbilt University, Nashville, TN, USA 3 Department of Psychiatry, University of Strasbourg, Strasb...