Three cases are described in which Stevens-Johnson syndrome progressed in the course of a few days to toxic epidermal necrolysis. Trimethoprim-sulfamethoxazole, allopurinol in combination with hydrochlorothiazide, phenytoin and possibly ampicillin were implicated in the causation of the disease.

Stevens-Johnson syndrome (SJS) has been described in the literature as a combination of erythematous blistering skin lesions covering <10% of body surface area and ≥1 mucous membrane erosion.1 SJS is usually triggered by a medication or infection. Infectious causes are more common in children, most notably herpes simplex virus (HSV) and Mycoplasma pneumoniae. Mucous membrane erosions without si...

Li-Ping Zou *, Chang-Hong Ding , Zhen-Jiang Song , Xiao-Feng Li c Department of Pediatrics, Chinese PLA General Hospital (No. 301 Hospital), Beijing, China Department of Neurology, Beijing Children’s Hospital, The Capital Medical University, Beijing, China Department of Cardiac Surgery, Beijing Children’s Hospital, The Capital Medical University, Beijing, China

Stevens-Johnson syndrome (SJS) has been described in the literature as a combination of erythematous blistering skin lesions covering <10% of body surface area and ≥1 mucous membrane erosion.1 SJS is usually triggered by a medication or infection. Infectious causes are more common in children, most notably herpes simplex virus (HSV) and Mycoplasma pneumoniae. Mucous membrane erosions without si...

Erythema Multiforme (EM) is specific acute hypersensitivity syndrome of multiple etiologies. It has distinct clinical pattern the hallmark of which, is the erythematous rash (so called iris or target lesions). Although a single type of lesion may predominate during a particular attack, the basic lesion of erythema multiforme are macular, urticarial and vesicobullous. The diagnosis of Erythema m...

A female schizophrenic patient who developed Stevens Johnson syndrome following carbamazepine treatment is reported. This life threatening condition is discussed in context of other adverse effects of the drug, reportedly found to be higher in frequency in the psychiatric population.