the annexin V Kozak sequence (Ϫ1CϾT) increases translation efficiency and plasma levels of annexin V, and decreases the risk of myocardial infarction in young patients. Agranulocytosis unresponsive to growth factors following rituximab in vivo purging Rituximab, a chimeric monoclonal anti-CD20 antibody, has been successfully used to in vivo purge CD20 ϩ tumor cells during mobilization for high-...

Myeloid cell lines and primary leukemic myeloblasts express two classes of granulocyte macrophage colony-stimulating factor (GM-CSF) binding sites of high (Kd 20-50 pM) and low affinity (Kd 5-10 nM). High affinity binding is caused by the association of two chains, p80 alpha and p130 beta, whereas p80 alpha alone confers low affinity binding only. Furthermore interleukin-3 (IL-3) competes for t...

A 44-year-old quadriplegic woman presented with fevers, hematuria, and a leukemoid reaction of >70,000 cells/mL. Workup for infectious etiologies was negative. A large bladder mass with bilateral lymphadenopathy was discovered by pelvic CT with biopsy revealing a dedifferentiated urothelioma. The cancer was deemed inoperable. The patient was subsequently found to have an elevated GCSF of 182.9 ...

The present study aimed at investigating the beneficial effects of co-administering granulocyte colony–stimulating factor (G-CSF) and stem cell factor (SCF) in a model of chronic liver injury induced by thioacetamide (TAA). Biochemical and histopathology- cal examinations were performed on serum and liver specimens. At the end of the treatment period, the rats were anesthetized with ether, seru...

OBJECTIVE To characterize and evaluate hematopoietic colony-stimulating factor (CSF) use, including cost implications, in US academic health centers. DESIGN An observational study of patients who received granulocyte colony-stimulating factor (G-CSF) or granulocyte-macrophage colony-stimulating factor (GM-CSF) from September 1 to October 15, 1993. SETTING Thirty academic health centers in t...

Experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis, can be induced by immunization with a number of myelin antigens. In particular, myelin oligodendrocyte glycoprotein, a central nervous system (CNS)-specific antigen expressed on the myelin surface, is able to induce a paralytic MS-like disease with extensive CNS inflammation and demyelination in several strains of ...

Discussion. The implantable system described in this report provides a method for delivering aqueous solutions to the external rabbit eye for at least 6 weeks. The PTFE tube is implanted in the superior conjunctival fornix 4 weeks prior to the implantation of the pump. During this time fibrous tissue ingrowth secures the tube firmly to the surrounding tissues. By allowing the tube to be anchore...

We show that 1,25-dihydroxyvitamin D3 (1,25[0H12D3), the most hormonally active metabolite of vitamin 113, modulates sensitively and specifically both the protein and messenger RNA accumulation of the multilineage growth factor granulocyte-macrophage colony-stimulating factor (GM-CSF). The regulation of GMCSF expression is seen in both normal human mitogen-activated T lymphocytes and T lymphocy...