A peptic ulcer is an erosion in a segment of the gastro intestinal mucosa, typically in the stomach (gastric ulcer) or first few centimeters of duodenum (duodenal ulcer) that penetrates through the muscularis mucosae. Contrary to popular belief, ulcer is not caused by spicy food but instead is most commonly due to either an infection or long term use of medications. Standard treatment is a comb...

The synchronous change in the antral release of gastrin and somatostatin into a vein draining the stomach was studied during acidic and alkaline intragastric pH in six anaesthetised duodenal ulcer patients and six controls after atropinisation. No differences in the basal secretion of gastrin and somatostatin were observed among the two groups. Alkaline as well as acidic intragastric pH had no ...

Objective: The present study was undertaken to evaluate the gastroprotective potential of Cajanus cajan seed aqueous extract (CCSE) on experimentally induced gastric ulcer in albino rats. Methods: Preliminary acute toxicity conducted determine oral median lethal dose (LD50). Twenty (20) male rats divided into 5 groups (A-E) 4 animals each were used. Group A (normal control) and B (ulcer model) ...

A perforated peptic ulcer in a child is a rare entity. Severe abdominal pain in an ill-appearing child with a rigid abdomen and possibly with signs of shock is the typical presenting feature of this life-threatening complication of peptic ulcer disease. We present a case of a 14.5-year-old adolescent girl who developed abdominal and shoulder pain that resolved after 1 day. She was then complete...

Working with the chloridropeptic ulcer, both duodenal and gastric ulcers, I would say that we have gained considerable experience. Over the years, we must not forget that everything happened in the pre-blocking stage of acid secretion era of the stomach; so, the chapter of chloridropptic ulcers today is mostly clinical. Occasionally we found a clinical and surgical picture with gastrectase, gas...

BACKGROUND Diabetes mellitus is an independent risk factor for impaired healing of peptic ulcers, and there are currently no supplementary therapeutics other than the standard antipeptic medicine to improve the ulcer healing in diabetes. This study examined the potential pleiotropic effect of a glucagon-like peptide (Glp)-1 analogue exendin (Ex)-4 on the regeneration of gastric ulcer in strepto...

Helicobacter pylori (H. pylori) is a spiral shaped bacterium that resides in the stomach mucosa. Isolation of H. pylori from the stomach mucosa changed the erstwhile widely held belief that the stomach contains no bacteria and is actually sterile. Once H. pylori is safely ensconced in the mucus, it is able to neutralize the acid in the stomach by elaborating an enzyme called urease. Urease conv...