The temperature distribution in human body regulates variety of biological mechanism. Human Skin is a very complex structure and abnormality in temperature of various layer of skin play important role for curing and treatment diseases like tumor, cancer etc. The eight layers of human skin namely stratum corneum, stratum lucidum, stratum granulosum, stratum spinosum, stratum germinativum, papill...

BACKGROUND Varicose veins commonly occur in the lower extremities and can cause pain and discomfort in the affected area. Many patients with varicose veins suffer from itching, but its cause has not been sufficiently explained. In recent years, the role of zinc in maintaining the integrity of skin has been reported, and zinc supplementation has been suggested to be effective in relieving itchin...

Lipids in the stratum corneum of atopic dermatitis (AD) patients differ substantially in composition from healthy subjects. We hypothesized that hyperactivated type 2 immune response alters AD skin lipid metabolism. We have analyzed stratum corneum lipids from nonlesional and lesional skin of AD subjects and IL-13 skin-specific Tg mice. We also directly examined the effects of IL-4/IL-13 on hum...

BACKGROUND Incontinence associated dermatitis (IAD) is an inflammatory skin disease mainly triggered by prolonged skin contact with urine, feces but also liberal detergent use when cleansing the skin. To minimize the epidermal barrier challenge we optimized the design of adult incontinence briefs. In the fluid absorption area we interposed a special type of acidic, curled-type of cellulose betw...

BACKGROUND AND OBJECTIVES Studies have demonstrated that some cutaneous biophysical properties vary with age, gender and body sites. However, the characteristics of the skin friction coefficient in different genders and age groups have not yet been well established. In the present study, we assess the skin friction coefficient in a larger Chinese population. METHODS A total of 633 subjects (3...

The outermost layer of the human skin, the stratum corneum (SC), is comprised of structurally inter-positioned anatomical regions. This inter-positioning renders the electrical characterization of its individual region difficult. To address this difficulty, the SC’s electrical properties at the cellular level were investigated. Impedance measurements were performed using a planar microelectrode...

Bee venom (BV) has long been used as a traditional medicine. The aim of the present study was to formulate a BV emulsion with good rheological properties for dermal application and investigate the effect of formulation on the permeation of melittin through dermatomed rat skin. A formulated emulsion containing 1% (w/v) BV was prepared. The emulsion was compared with distilled water (DW) and 25% ...

Dermoscopy has been incorporated as a useful dermatologic diagnostic tool in recent years. Its original indication----the differential diagnosis of pigmented lesions----has been broadened to include other noncancerous skin diseases, such as diseases of the hair, psoriasis, scabies, and connective tissue diseases. We report a case in which dermoscopy was used to rule out a pigmented plantar lesi...

The epidermis has developed physical and immunological barriers that prevent infiltration of deleterious chemicals and pathogens. As a first step to understanding the relationship between these barriers, we investigated whether TLR2 activation functionally alters tight junctions (TJs) in cultured human keratinocytes. Stimulation with peptidoglycan, a ligand for TLR2, elevated the TJ-associated ...