نتایج جستجو برای: stress polycythemia
تعداد نتایج: 444064 فیلتر نتایج به سال:
The Philadelphia-negative chronic myeloproliferative neoplasms - essential thrombocythemia (ET), polycythemia vera (PV), and myelofibrosis (MF) (MPNs) - have recently been shown to be associated with chronic inflammation, oxidative stress and accumulation of reactive oxygen species (ROS). Using whole blood transcriptional profiling, we report that several oxidative stress and anti-oxidative str...
BACKGROUND A somatic activating mutation (V617F) in the JAK2 tyrosine kinase was recently discovered in the majority of patients with polycythemia vera (PV), and some with essential thrombocythemia (ET) and chronic idiopathic myelofibrosis. However, the role of mutant JAK2 in disease pathogenesis is unclear. METHODS AND FINDINGS We expressed murine JAK2 WT or V617F via retroviral bone marrow ...
By BARUCH MODAN I HE USE of pa2 in the therapy of polycythemia vera has continued to be a controversial subject since it was first introduced.15”5 Although considered as the ultimate treatment for polycythemia vera by many hematologists it has, on the other hand, been discredited by others as being responsible for a high proportion of deaths from acute leukemia. The main obstacle to an objectiv...
The diagnostic value in polycythemia of the presence of endogenous erythroid colonies derived from bone marrow cells (EECs) was assessed in a prospective study on 108 patients referred for polycythemia (Hb greater than g/dL in men, greater than 16 g/dL in women) with normal plasma volume by comparison with the standard criteria, the bone marrow grade, and the serum erythropoietin (Epo) level. T...
By BARUCH MODAN I HE USE of pa2 in the therapy of polycythemia vera has continued to be a controversial subject since it was first introduced.15”5 Although considered as the ultimate treatment for polycythemia vera by many hematologists it has, on the other hand, been discredited by others as being responsible for a high proportion of deaths from acute leukemia. The main obstacle to an objectiv...
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