1Department of Biochemistry, College of Sciences, Yonsei University, Seoul, Republic of Korea; 2Department of Molecular and Cellular Biochemistry, School of Medicine, Kangwon National University, Chunchon, Kangwon-Do, Republic of Korea; 4Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea; 5Seoul Artificial Eye...

It is known that the analyses of complex structures can be affected by a great uncertainties and approximations. The paper schedules these approximations in three groups: numerical errors, modelling errors and human errors. After a brief discussion of these approximations, the paper put in evidence the importance to planning the numerical analysis of complex structures using different models, v...

Employee portals are systems that provide employees with the timely and relevant information that they need to perform their duties and to make efficient business decisions. Although their use is widespread, the question on how benefits of these portals are materialized for their users has not been fully answered yet. Thus, the purpose of this paper is to gain a better understanding of the util...

This paper empirically investigates whether information technology (IT) strategies, business strategies, and divisions are aligned to meet overall business goals for Korean Small and medium-sized enterprises (SMEs), based on structure based Strategic Alignment Model, and make comparison with those of Japanese SMEs. Using 2,869 valid responses of Korean Human Capital Corporate Panel survey, a re...

Several specific functions have been assigned to the S-layer from different microorganisms (protective coats, molecular sieves, molecule and ion traps, cell adhesion and surface recognition, virulence factors). These potential functions have converted the S-layers in attractive targets for biophysical studies and structural research, particularly in regard to their possible nanotechnological ap...

Robust methods to detect DNA-binding proteins from structures of unknown function are important for structural biology. This paper describes a method for identifying such proteins that (i) have a solvent accessible structural motif necessary for DNA-binding and (ii) a positive electrostatic potential in the region of the binding region. We focus on three structural motifs: helix-turn-helix (HTH...

Human factors research in conceptual modeling is scarce. Recently, quality assurance frameworks, methods and tools for conceptual schemas have received increased research attention, but the perception of quality by schema users has largely been ignored in this stream of research. This paper proposes a tentative model of user beliefs and attitudes towards the quality of conceptual schemas. The p...

Controlling protein dimerization with small molecules has broad application to the study of protein function. Rapamycin has two binding surfaces: one that binds to FKBP12 and the other to the Frb domain of mTor/FRAP, directing their dimerization. Rapamycin is a potent cell growth inhibitor, but chemical modification of the surface contacting Frb alleviates this effect. Productive interactions w...

Information technology outsourcing is one of the factors affecting the improvement of flexibility and dynamics of enterprises in the competitive environment. Also, the study of the factors affecting its success has been always considered by business owners and the area of research. Professional experiences and research results consider that the success of IT (Information technology) outsourcing...

Chemotactic stimulation of vegetative or aggregative Dictyostelium discoideum cells induced a transient elevation of cyclic GMP levels. The addition of chemoattractants to postvegetative cells by pulsing induced phosphodiesterase activity. The following lines of evidence suggest a messenger function for cyclic GMP in the induction of phosphodiesterase: (i) Folic acid and cyclic AMP increased cy...