Diabetic nephropathy is one of the major complications of diabetes. In recent years, several plant extracts and herbal formulations are used as antidiabetic formulations. It has been suggested that Eruca sativa exert a beneficial antidiabetic effect in rats by reducing oxidative stress. The present research work was designed to evaluate the effect of methanolic and aqueous extracts of Eruca sat...

OBJECTIVE Mesenchymal stem cells (MSCs) have been reported to secrete various cytokines that exhibit angiogenic and neurosupportive effects. This study was conducted to investigate the effects of MSC transplantation on diabetic polyneuropathy (DPN) in rats. RESEARCH DESIGN AND METHODS MSCs were isolated from bone marrow of adult rats and transplanted into hind limb skeletal muscles of rats wi...

Abstract Background Changes in blood lipid level (dyslipidemia) play a central role the onset and pathogenesis of macrovascular complications diabetes mellitus. Traditional herbal healers commonly use anti-diabetic polyherbal formulations to provide multi-therapeutic approach for treatment mellitus its associated complications. The effect aqueous leaf extracts Leptadenia hastata (pers) Decne, M...

metalloproteinases and tissue inhibitors of matrix metalloproteinases at multiple levels of regulation. Retardation of wound healing is one of complications in diabetes mellitus due to increased collagenase activity and reduced granulation tissue in the diabetic wound. Studies on wound healing in streptozotocin (STZ)-induced diabetic rats suggested the possibility that the reduced breaking woun...

interleukin-1β (il-1β) has a role in β- cell destruction in autoimmune diabetes by stimulating the expression of inducible nitric oxide synthase (inos) that generates the free radical nitric oxide. we aimed to investigate the effect of achillea millefolium l, as a traditional hypoglycemic agent, on il-1β and inos gene expression of pancreatic tissue in the stz- induced diabetic rats. forty adul...

Diabetic retinopathy (DR), the most ordinary and specific microvascular complication of diabetes, is a disease of the retina. Zerumbone (ZER) is a monocyclic sesquiterpene compound, and based on reports, it is the predominant bioactive compound from the rhizomes of Zingiber zerumbet. The aim of the current study is to evaluate the protective effect of zerumbone against DR in streptozotocin (STZ...

The antioxidant activities of fermented red ginseng (FRG) were investigated in vitro and in vivo. The contents of total polyphenol and total flavonoid in FRG extracts were 17.01±2.00 μg/mg and 18.42±3.97 μg/mg, respectively. These extracts were capable of directly scavenging α, α-diphenyl-picrylhydrazyl free radicals. The antioxidative effects of the FRG extracts in streptozotocin (STZ)-induced...

Molecular mechanisms of the beneficial effects of angiotensin-(1-7), Ang-(1-7), in diabetes-related complications, including erectile dysfunction, remain unclear. We examined the effect of diabetes and/or Ang-(1-7) treatment on vascular reactivity and cyclic guanosine monophosphate (cGMP) phosphodiesterase (PDE) in corpus cavernosum. Male Wistar rats were grouped as (1) control, (2) diabetic (s...

PURPOSE To test whether chronic memantine (MEM) treatment improves retinal function and prevents neurodegeneration and vascular changes in the retinas of streptozotocin (STZ)-induced diabetic rats. METHODS Based on basal body weight and blood glucose, Brown Norway (BN) rats were divided into three groups. One group of rats was treated with vehicle (VEH), and the other two groups were treated ...

Diabetes mellitus is a complex disease characterised by chronic hyperglycaemia due to compromised insulin synthesis and secretion, or decreased tissue sensitivity to insulin, if not all three conditions. Endothelial dysfunction is a common complication in diabetes in which endothelium-dependent vasodilation is impaired. The aim of this study was to examine the involvement of TRPV4 in diabetes e...