An expeditious one-pot, ligand-free, Pd(OAc)2-catalyzed, three-component reaction for the synthesis of 2,3-diarylimidazo[1,2-a]pyridines was developed under microwave irradiation. With the high availability of commercial reagents and great efficiency in expanding molecule diversity, this methodology is superior to the existing procedures for the synthesis of 2,3-diarylimidazo[1,2-a]pyridines an...

The ammonium salts of many drugs have significantly improved the solubility and, accordingly, bioavailability medicinal substances in human body. 5-(4-Hydroxy-2-oxo-2H-chromen-3-yl)-5H-chromeno[2,3-b]pyridines are potential NPY1R ligands, which attractive for antiobesity treatment. Ammonium 5H-chromeno[2,3-b]pyridines were previously unknown. In this communication, it was found that four-compon...

Catalytic reactions which involve the cleavage of an sp3 C–H bond adjacent to a nitrogen atom in N-2pyridynyl alkylamines are described. The use of Ru3(CO)12 as the catalyst results in the addition of the sp3 C–H bond across alkene bond to give the coupling products. A variety of alkenes, including terminal, internal, and cyclic alkenes, can be used for the coupling reaction. The presence of di...

A convenient and efficient application of microencapsulated/methylrhenium trioxide (MTO) and MTO/pyridine systems for the selective oxidation of cardanol derivatives is reported. Environmentally friendly and low-cost H2O2 was used as the oxygen atom donor. The catalysts were stable systems for at least five recycling experiments. In the oxidation of C2 alkyl-substituted cardanol derivatives, hi...

A series of new poly-functionalized two-carbon-tethered fused acridine/indole pairs were synthesized via Brønsted acid-promoted domino reactions between indoline-2,3-dione and C(2)-tethered indol-3-yl enaminones. The reactions were further expanded to prepare C-tethered fused acridine/pyridine pairs, N-substituted amino acids, N-cyclopropyl and N-aryl substituted fused acridine derivatives, as ...

Both (PNP)Re(H)(4) and (PNP)ReH(cyclooctyne) (PNP(i)(Pr) = ((i)Pr(2)PCH(2)SiMe(2))(2)N) react with alkylpyridines NC(5)H(4)R to give first (PNP)ReH(2)(eta(2)-pyridyl) and cyclooctene and then, when not sterically blocked, (PNP)Re(eta(2)-pyridyl)(2) and cyclooctane. The latter are shown by NMR, X-ray diffraction, and DFT calculations to have several energetically competitive isomeric structures ...

The title compound, C21H9F10N3, represents a potential redox non-innocent pyridine di-imine ligand system. It consists of a central pyridine ring with two penta-fluoro-phenyl substituted imine groups in positions 2 and 6. The whole mol-ecule is generated by mirror symmetry, the mirror bis-ecting the N and para-C atom of the pyridine ring. The perfluoro-phenyl ring is inclined to the pyridine ri...