Drug efficacy strongly relies on the solid state of active pharmaceutical ingredient. Classical solid-state screening methods involve different solvent compositions and supersaturations. Moreover, many repeat experiments needed to address stochasticity nucleation make this approach costly. This paper presents a newly developed modular microfluidic platform that provides universal flexible plug-...

6. Urinary tract infections.?In acute cystitis and pyelitis and in chronic infection due to coli bacilli sulphanilamide is adequate but sulphacetamide has been particularly recommended because of its high solubility in urine. Its sodium salt (albucid soluble) may be injected intravenously in 30 per cent solution. Sulphathiazole or sulphadiazine may be given in resistant cases. The average daily...

Ten years ago, Waksman and Lechevaller1 demonstrated the important antibiotic action of neomycin against the Koch bacillus. The effect of neomycin is even greater than that of streptomycin. Rake, Hobby and Donovick' have also demonstrated the antibiotic effect of neomycin in experimental tuberculosis. Because of its toxicity, Grumbach and Rist3 considered that parenteral neomycin injection was ...

In spite of the universal use of sulphonamides there have apparently been reports of the occurrence of purpura following their administration on only twenty-two occasions. In fourteen cases the thrombocytes were found to be reduced in number, absent from blood films or below 100,000 per c.mm.; in four cases the thrombocyte count exceeded 125,000 per c.mm. and in four the count was not recorded....

Sir,?There are two points arising from your December editorial on the treatment of acute baeillary dysentery on which I think further comment to be necessary. These are, first, the absorption of sulphapyridine from the gastro-intestinal tract, and second, the mention of chronic baeillary dysentery. To deal with absorption first : the rate of absorption of the sulphonamides varies directly, with...

nitely diagnosed as cerebrospinal fever. Of these 50 cases, 29 were treated as in-patients in the Infectious Diseases Ward of the Local Civil Hospital. Eleven cases were treated outside the hospital by isolating the patients, as far as possible, in their own houses. The remaining 10 cases either refused treatment of any kind or were treated by the local unqualified practitioners. Of this last g...

Sulfonamide drugs enter the environment in different ways, eg through wastewater, creating the potential risk of the generation of drug resistant strains of microorganisms. This risk increases when drugs are resistant to degradation and remain in the environment for a long time. Therefore, it is particularly important to know biodegradability of sulfa drugs since the literature data on this sub...