Nrf2 defense is a very important cellular mechanism to control oxidative stress, which is implicated in wound healing. Nrf2 can induce many cytoprotective genes, including HO-1, NQO1 and G6PD. Among many natural products that have been reported as Nrf2 activators, sulforaphane and curcumin have been studied more widely than any others, and both are in clinical trials for non-cancerous disorders...

Activation of Nrf2 by Ischemic Preconditioning and Sulforaphane in Renal Ischemia/Reperfusion Injury: A Comparative Experimental Study By Ahmed A. Shokeir*, Nashwa Barakat*, Abdelaziz M. Hussein†, Amira Awadalla*, Ahmed Harraz*, Shery Khater*, Kamel Hemmaid $ , Ahmed I. Kamal* From *Urology and Nephrology Center, †Physiology Department, Faculty of Medicine, Mansoura, University, $ Faculty of Sc...

The isothiocyanates sulforaphane and PEITC (beta-phenethyl isothiocyanate) as well as the indoles indole-3-carbinol and its condensation product 3,3'-diindolylmethane are known to inhibit cancer cell proliferation and induce apoptosis. In this study, we compared the cell growth inhibitory potential of the four compounds on the p53 wild type human colon cancer cell line 40-16 (p53(+/+)) and its ...

Induction of phase 2 detoxication enzymes [e.g., glutathione transferases, epoxide hydrolase, NAD(P)H: quinone reductase, and glucuronosyltransferases] is a powerful strategy for achieving protection against carcinogenesis, mutagenesis, and other forms of toxicity of electrophiles and reactive forms of oxygen. Since consumption of large quantities of fruit and vegetables is associated with a st...

Background: The Purpose of this study was to investigate the effects sulforaphane glucosinolate (SGS) from broccoli seed extracts on immune function and common cold symptoms in healthy Japanese adults.Methods: This randomized, placebo-controlled, double-blind, parallel-group comparison conducted adults who had worse health-related quality life SF-8 were more likely catch colds October 22, 2020 ...

The impact of exogenous sulfate components on the nutritional quality vegetables has been well documented. In this study, we examined effects adding K2SO4 to broccoli its quality, active components, and genes involved in glucosinolate synthesis. Different concentrations 25, 75, 150 g·m−2 were applied “Naihan Youxiu” cultivar, while control treatment received no potassium sulfate. Our primary ob...