نتایج جستجو برای: sulfoxides
تعداد نتایج: 3344 فیلتر نتایج به سال:
The Front Cover shows the introduction of fluorinated groups into molecules, which gives them interesting and sometimes unexpected physicochemical properties reactivity. In this study, configurational stability fluoroalkyl sulfoxides (shown on flyer) was investigated pKa value -CHF2 group determined, is very important for medicinal agrochemical research. picture reminiscent “Kinder Surpise”® wh...
Inducing α-helicity through side-chain cross-linking is a strategy that has been pursued to improve peptide conformational rigidity and bio-availability. Here we describe the preparation of small peptides tethered to chiral sulfoxide-containing macrocyclic rings. Furthermore, a study of structure-activity relationships (SARs) disclosed properties with respect to ring size, sulfur position, oxid...
Oxidized methionine residues in peptide thioesters can be reduced rapidly with NH4I to the corresponding sulfide by using Me2S as coreductant. Comparative reduction studies employing a 28-amino acid peptide thioester with an N-terminal methionine oxide as model system revealed the importance of the Me2S addition to avoid hydrolysis of the reactive thioester functionality. In addition, an NH4I-M...
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