1. Garratt KN, Brady PA, Hassinger NL, Grill DE, Terzic A, Holmes DR Jr. Sulfonylurea drugs increase early mortality in patients with diabetes mellitus after direct angioplasty for acute myocardial infarction. J Am Coll Cardiol 1999;33:119–24. 2. The University Group Diabetes Program. A study of the effect of hypoglycemic agents on vascular complications in patients with adultonset diabetes. VI...

Diabetes mellitus is a primary cause for large number of pathophysiologic co-morbidities including obesity, hypertension, hyperlipidemia, atherosclerosis. Obesity is intimately associated with diabetes, which is not only a major but also a costly healthcare problem for the individual and to the society. The World Health Organization (WHO) estimates that approximately 135 million people worldwid...

Background and Aim. Diabetes mellitus is a chronic disease that has a great impact on patients and society. Metformin monotherapy is capable of maintaining a target glycemic control only for a short term. The aim of this study was to determine the efficacy of combination therapy of metformin with any antidiabetic agents in type 2 diabetes mellitus (T2DM) patients. Methods. Reports of randomized...

1. Garratt KN, Brady PA, Hassinger NL, Grill DE, Terzic A, Holmes DR Jr. Sulfonylurea drugs increase early mortality in patients with diabetes mellitus after direct angioplasty for acute myocardial infarction. J Am Coll Cardiol 1999;33:119–24. 2. The University Group Diabetes Program. A study of the effect of hypoglycemic agents on vascular complications in patients with adultonset diabetes. VI...

Diabetes Mellitus is a metabolic disorder characterized by the presence of hyperglycaemia due to defective insulin secretion, insulin action or both. The estimated number of people with diabetes registered in India was 50.8 million in the 2010 and diabetes will be affecting 87 million persons by 2030. A prospective cross-sectional study was conducted in the outpatient Department of Medicine in ...

We investigated the association between the risk of herpes zoster (HZ) and diabetes-related macrovascular comorbidities and microvascular disorders in diabetic patients. This retrospective study included 25,345 patients with newly identified HZ and age- and gender-matched controls retrieved from the National Health Insurance Research Database in Taiwan during the period of 2005 to 2011. Multiva...

Exenatide is a GLP-1 (glucagon-like peptide-1) agonist that has been approved in the UK for use in the management of Type 2 Diabetes Mellitus (T2DM) since 2006. It acts by increasing glucose-induced insulin release and by reducing glucagon secretion postprandially. It therefore increases insulin secretion and reduces glucose levels, especially postprandially. It also reduces gastric emptying an...

An investigation of serum immunoreactive trypsin concentration and pancreatic isoamylase activity in patients with diabetes mellitus has shown that exocrine pancreatic deficit is maximal in insulin dependent diabetics, intermediate in those controlled with sulphonylureas, and absent in patients controlled with biguanides or diet or both. A significant correlation between the serum concentration...

Ion channels present in the plasma membrane and intracellular organelles of all cells, play an important role in maintaining cellular integrity, smooth muscle contraction, secretion of hormones and neurotransmitters. Among the ion channels, potassium channels (K(+)) are the most abundant having important role in cardiac repolarization, smooth muscle relaxation and insulin release. These are als...